Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Distinct structural and functional epitopes of the alpha E beta 7 integrin.

Authors: Authors: Russell GJ, Parker CM, Cepek KL, Mandelbrot DA, Sood A, Mizoguchi E, Ebert EC, Brenner MB, Bhan AK.
Eur J Immunol 1994-11-01
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TCR usage and functional capabilities of human gamma delta T cells at birth.

Authors: Authors: Morita CT, Parker CM, Brenner MB, Band H.
J Immunol 1994-11-01
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Nonpeptide ligands for human gamma delta T cells.

Authors: Authors: Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT.
Proc Natl Acad Sci U S A 1994-08-16
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Murine M290 integrin expression modulated by mast cell activation.

Authors: Authors: Smith TJ, Ducharme LA, Shaw SK, Parker CM, Brenner MB, Kilshaw PJ, Weis JH.
Immunity 1994-08-01
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Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-basolateral membrane apposition.

Authors: Authors: Kaoutzani P, Colgan SP, Cepek KL, Burkard PG, Carlson S, Delp-Archer C, Brenner MB, Madara JL.
J Clin Invest 1994-08-01
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Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum.

Authors: Authors: Rajagopalan S, Brenner MB.
J Exp Med 1994-07-01
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Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.

Authors: Authors: Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM.
J Biol Chem 1994-03-25
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Calnexin: a membrane-bound chaperone of the endoplasmic reticulum.

Authors: Authors: Bergeron JJ, Brenner MB, Thomas DY, Williams DB.
Trends Biochem Sci 1994-03-01
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Evidence for a structural difference in the CD7 polypeptide on human thymocytes and intraepithelial lymphocytes defined by a new monoclonal antibody, 3D9.

Authors: Authors: Russell GJ, Parker CM, Cepek KL, Brenner MB, Bhan AK.
Cell Immunol 1994-03-01
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Retention of unassembled components of integral membrane proteins by calnexin.

Authors: Authors: Rajagopalan S, Xu Y, Brenner MB.
Science 1994-01-21
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