Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum.

Authors: Authors: Schreiber KL, Bell MP, Huntoon CJ, Rajagopalan S, Brenner MB, McKean DJ.
Int Immunol 1994-01-01
View full abstract on Pubmed

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

Authors: Authors: Porcelli S, Yockey CE, Brenner MB, Balk SP.
J Exp Med 1993-07-01
View full abstract on Pubmed

Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients.

Authors: Authors: DerSimonian H, Sugita M, Glass DN, Maier AL, Weinblatt ME, Rème T, Brenner MB.
J Exp Med 1993-06-01
View full abstract on Pubmed

Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin).

Authors: Authors: David V, Hochstenbach F, Rajagopalan S, Brenner MB.
J Biol Chem 1993-05-05
View full abstract on Pubmed

Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells.

Authors: Authors: Cepek KL, Parker CM, Madara JL, Brenner MB.
J Immunol 1993-04-15
View full abstract on Pubmed

Alpha 4/180, a novel form of the integrin alpha 4 subunit.

Authors: Authors: Parker CM, Pujades C, Brenner MB, Hemler ME.
J Biol Chem 1993-04-05
View full abstract on Pubmed

CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen.

Authors: Authors: Porcelli S, Morita CT, Brenner MB.
Nature 1992-12-10
View full abstract on Pubmed

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

Authors: Authors: Hochstenbach F, David V, Watkins S, Brenner MB.
Proc Natl Acad Sci U S A 1992-05-15
View full abstract on Pubmed

A family of beta 7 integrins on human mucosal lymphocytes.

Authors: Authors: Parker CM, Cepek KL, Russell GJ, Shaw SK, Posnett DN, Schwarting R, Brenner MB.
Proc Natl Acad Sci U S A 1992-03-01
View full abstract on Pubmed

Oligoclonality of human intestinal intraepithelial T cells.

Authors: Authors: Van Kerckhove C, Russell GJ, Deusch K, Reich K, Bhan AK, DerSimonian H, Brenner MB.
J Exp Med 1992-01-01
View full abstract on Pubmed