Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Functionally distinct subsets of human gamma/delta T cells.

Authors: Authors: Morita CT, Verma S, Aparicio P, Martinez C, Spits H, Brenner MB.
Eur J Immunol 1991-12-01
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A predominance of the T cell receptor V gamma 2/V delta 2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition.

Authors: Authors: Panchamoorthy G, McLean J, Modlin RL, Morita CT, Ishikawa S, Brenner MB, Band H.
J Immunol 1991-11-15
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"Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire".

Authors: Authors: DerSimonian H, Band H, Brenner MB.
J Exp Med 1991-11-01
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Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes.

Authors: Authors: Denning SM, Jones DM, Ware RE, Weinhold KJ, Brenner MB, Haynes BF.
Int Immunol 1991-10-01
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Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire.

Authors: Authors: DerSimonian H, Band H, Brenner MB.
J Exp Med 1991-09-01
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Predominant T cell receptor V gene usage in patients with abnormal clones of B cells.

Authors: Authors: Janson CH, Grunewald J, Osterborg A, DerSimonian H, Brenner MB, Mellstedt H, Wigzell H.
Blood 1991-04-15
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Biology of the human gamma delta T-cell receptor.

Authors: Authors: Porcelli S, Brenner MB, Band H.
Immunol Rev 1991-04-01
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Antigens and antigen-presenting molecules for gamma delta T cells.

Authors: Authors: Band H, Porcelli SA, Panchamoorthy G, McLean J, Morita CT, Ishikawa S, Modlin RL, Brenner MB.
Curr Top Microbiol Immunol 1991-01-01
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Gamma delta T cells in leprosy lesions.

Authors: Authors: Uyemura K, Band H, Ohmen J, Brenner MB, Rea TH, Modlin RL.
Curr Top Microbiol Immunol 1991-01-01
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Recognition of mycobacterial antigens by gamma delta T cells.

Authors: Authors: Band H, Panchamoorthy G, Mclean J, Morita CT, Ishikawa S, Modlin R, Brenner MB.
Res Immunol 1990-09-01
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