Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire.

Authors: Authors: Parker CM, Groh V, Band H, Porcelli SA, Morita C, Fabbi M, Glass D, Strominger JL, Brenner MB.
J Exp Med 1990-05-01
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Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line.

Authors: Authors: Solomon KR, Krangel MS, McLean J, Brenner MB, Band H.
J Immunol 1990-03-01
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Newly identified gamma delta and beta delta T-cell receptors.

Authors: Authors: Hochstenbach F, Brenner MB.
J Clin Immunol 1990-01-01
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Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes.

Authors: Authors: Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA.
Nature 1989-10-05
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A novel monoclonal antibody, 1B3.1, binds to a new epitope of the VLA-1 molecule.

Authors: Authors: Bank I, Hemler M, Brenner MB, Cohen D, Levy V, Belko J, Crouse C, Chess L.
Cell Immunol 1989-09-01
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T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer.

Authors: Authors: Hochstenbach F, Brenner MB.
Nature 1989-08-17
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Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions.

Authors: Authors: Modlin RL, Pirmez C, Hofman FM, Torigian V, Uyemura K, Rea TH, Bloom BR, Brenner MB.
Nature 1989-06-15
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Expression of human T cell receptor-gamma delta structural forms.

Authors: Authors: Band H, Hochstenbach F, Parker CM, McLean J, Krangel MS, Brenner MB.
J Immunol 1989-05-15
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Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.

Authors: Authors: Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB.
J Exp Med 1989-04-01
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Human T cell receptor gamma delta structure.

Authors: Authors: Brenner MB, Hochstenbach F, Band H, Parker C, McLean J, Hata S, Krangel M.
Adv Exp Med Biol 1989-01-01
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