Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Characteristics of 27 human T-cell leukemia cell lines with/without T-cell receptors of T3-Ti alpha beta or T3-Ti gamma delta complex.
Authors: Authors: Minowada J, Kohno K, Matsuo Y, Drexler HG, Ohnuma T, Tax WJ, Brenner MB.
Haematol Blood Transfus
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Expression of T cell receptor delta chains in benign and malignant T lineage lymphoproliferations.
Authors: Authors: Picker LJ, Brenner MB, Michie S, Warnke RA.
Am J Pathol
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T cells expressing gamma delta chain receptors in rheumatoid arthritis.
Authors: Authors: Brennan FM, Londei M, Jackson AM, Hercend T, Brenner MB, Maini RN, Feldmann M.
J Autoimmun
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Extensive junctional diversity of rearranged human T cell receptor delta genes.
Authors: Authors: Hata S, Satyanarayana K, Devlin P, Band H, McLean J, Strominger JL, Brenner MB, Krangel MS.
Science
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The gamma delta T cell receptor.
Authors: Authors: Brenner MB, Strominger JL, Krangel MS.
Adv Immunol
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Discordant expression of CD3 and T-cell receptor beta-chain antigens in T-lineage lymphomas.
Authors: Authors: Picker LJ, Brenner MB, Weiss LM, Smith SD, Warnke RA.
Am J Pathol
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Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit.
Authors: Authors: Band H, Hochstenbach F, McLean J, Hata S, Krangel MS, Brenner MB.
Science
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Identification of putative human T cell receptor delta complementary DNA clones.
Authors: Authors: Hata S, Brenner MB, Krangel MS.
Science
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T-cell receptors of human suppressor cells.
Authors: Authors: Modlin RL, Brenner MB, Krangel MS, Duby AD, Bloom BR.
Nature
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Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes.
Authors: Authors: Krangel MS, Band H, Hata S, McLean J, Brenner MB.
Science
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