Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.

Authors: Authors: Krangel MS, Bierer BE, Devlin P, Clabby M, Strominger JL, McLean J, Brenner MB.
Proc Natl Acad Sci U S A 1987-06-01
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Isolation of anti-idiotypic antibodies to T cells using an anti-framework determinant antibody.

Authors: Authors: Maecker HT, Kitamura K, Brenner MB, Levy R.
J Immunol Methods 1987-04-16
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Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes.

Authors: Authors: Brenner MB, McLean J, Scheft H, Riberdy J, Ang SL, Seidman JG, Devlin P, Krangel MS.
Nature 1987-03-19
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Characterization and expression of the human alpha beta T cell receptor by using a framework monoclonal antibody.

Authors: Authors: Brenner MB, McLean J, Scheft H, Warnke RA, Jones N, Strominger JL.
J Immunol 1987-03-01
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Identification of a putative second T-cell receptor.

Authors: Authors: Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.
Nature 1986-07-10
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A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.

Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
Nature 1986-07-10
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Clonal T lymphocyte recognition of the fine structure of the HLA-A2 molecule.

Authors: Authors: Brenner MB, McLean J, Yang SY, van der Poel JJ, Pious D, Strominger JL.
J Immunol 1985-07-01
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VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation.

Authors: Authors: Hemler ME, Jacobson JG, Brenner MB, Mann D, Strominger JL.
Eur J Immunol 1985-05-01
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Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit.

Authors: Authors: Brenner MB, Trowbridge IS, Strominger JL.
Cell 1985-01-01
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A study of the specificity of the direct binding between bacteria and HLA antigens.

Authors: Authors: Maeda K, Kono D, Kobayashi S, Brenner MB, Yu DT.
Clin Exp Immunol 1984-09-01
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