Frederick W. Alt

Frederick W. Alt, PhD

Charles A. Janeway Professor of Pediatrics

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.

Authors: Authors: Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA.
Nat Genet 2018-08-01
View full abstract on Pubmed

?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Authors: Authors: Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L.
Nat Immunol 2018-05-01
View full abstract on Pubmed

Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection.

Authors: Authors: Michelet X, Tuli A, Gan H, Geadas C, Sharma M, Remold HG, Brenner MB.
J Immunol 2018-05-01
View full abstract on Pubmed

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

Authors: Authors: Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB.
Nat Commun 2018-02-23
View full abstract on Pubmed

Functional genomics of stromal cells in chronic inflammatory diseases.

Authors: Authors: Slowikowski K, Wei K, Brenner MB, Raychaudhuri S.
Curr Opin Rheumatol 2018-01-01
View full abstract on Pubmed

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.

Authors: Authors: Chang SK, Kohlgruber AC, Mizoguchi F, Michelet X, Wolf BJ, Wei K, Lee PY, Lynch L, Duquette D, Ceperuelo-Mallafré V, Banks AS, Brenner MB.
J Clin Invest 2017-09-01
View full abstract on Pubmed

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.

Authors: Authors: Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.
Proc Natl Acad Sci U S A 2017-08-01
View full abstract on Pubmed

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity.

Authors: Authors: Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L.
Immunity 2017-02-21
View full abstract on Pubmed

Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators.

Authors: Authors: Nguyen HN, Noss EH, Mizoguchi F, Huppertz C, Wei KS, Watts GFM, Brenner MB.
Immunity 2017-02-21
View full abstract on Pubmed

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.

Authors: Authors: Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB.
Nature 2017-02-01
View full abstract on Pubmed