Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.
Authors: Authors: Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.
Proc Natl Acad Sci U S A
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Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators.
Authors: Authors: Nguyen HN, Noss EH, Mizoguchi F, Huppertz C, Wei KS, Watts GFM, Brenner MB.
Immunity
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Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity.
Authors: Authors: Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L.
Immunity
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Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.
Authors: Authors: Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB.
Nature
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Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration.
Authors: Authors: Birtolo C, Pham H, Morvaridi S, Chheda C, Go VL, Ptasznik A, Edderkaoui M, Weisman MH, Noss E, Brenner MB, Larson B, Guindi M, Wang Q, Pandol SJ.
Am J Pathol
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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Authors: Authors: Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM.
Wellcome Open Res
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Activation strategies for invariant natural killer T cells.
Authors: Authors: Kohlgruber AC, Donado CA, LaMarche NM, Brenner MB, Brennan PJ.
Immunogenetics
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A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair.
Authors: Authors: Encarnação M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, Santarino I, Hsu VW, Brenner MB, Barral DC, Vieira OV.
J Cell Biol
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Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.
Authors: Authors: Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.
J Immunol
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Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149.
Authors: Authors: Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.
J Immunol
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