Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Human autoreactive T cells recognize CD1b and phospholipids.

Authors: Authors: Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.
Proc Natl Acad Sci U S A 2016-01-12
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Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types.

Authors: Authors: Noss EH, Nguyen HN, Chang SK, Watts GF, Brenner MB.
Proc Natl Acad Sci U S A 2015-12-01
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Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.

Authors: Authors: Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB.
J Immunol 2015-09-15
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Immune cell profiling to guide therapeutic decisions in rheumatic diseases.

Authors: Authors: Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S.
Nat Rev Rheumatol 2015-09-01
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Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.

Authors: Authors: Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.
Arthritis Res Ther 2015-05-15
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Characterization of polar lipids of Listeria monocytogenes by HCD and low-energy CAD linear ion-trap mass spectrometry with electrospray ionization.

Authors: Authors: Tatituri RV, Wolf BJ, Brenner MB, Turk J, Hsu FF.
Anal Bioanal Chem 2015-03-01
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MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.

Authors: Authors: Michelet X, Garg S, Wolf BJ, Tuli A, Ricciardi-Castagnoli P, Brenner MB.
J Immunol 2015-03-01
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The transcriptional programs of iNKT cells.

Authors: Authors: Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB.
Semin Immunol 2015-02-01
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RNAi screens of lysosomal trafficking.

Authors: Authors: Garg S, Brenner MB.
Methods Cell Biol 2015-01-01
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Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.

Authors: Authors: Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB.
Nat Immunol 2015-01-01
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