Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.

Authors: Authors: Brennan PJ, Tatituri RV, Heiss C, Watts GF, Hsu FF, Veerapen N, Cox LR, Azadi P, Besra GS, Brenner MB.
Proc Natl Acad Sci U S A 2014-09-16
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Pillars article: analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- a/ß T cells demonstrates preferential use of several Vß genes and an invariant TCR a chain. J. Exp. Med. 1993. 178: 1-16.

Authors: Authors: Porcelli S, Yockey CE, Brenner MB, Balk SP.
J Immunol 2014-08-01
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Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

Authors: Authors: Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S.
PLoS Genet 2014-06-01
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Soft matrix is a natural stimulator for cellular invasiveness.

Authors: Authors: Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB.
Mol Biol Cell 2014-02-01
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iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo .

Authors: Authors: Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.
Cancer Immunol Res 2014-01-01
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Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

Authors: Authors: Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB.
Mol Biol Cell 2013-12-01
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Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.

Authors: Authors: Hu X, Kim H, Brennan PJ, Han B, Baecher-Allan CM, De Jager PL, Brenner MB, Raychaudhuri S.
Proc Natl Acad Sci U S A 2013-11-19
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CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells.

Authors: Authors: Sanderson JP, Brennan PJ, Mansour S, Matulis G, Patel O, Lissin N, Godfrey DI, Kawahara K, Zähringer U, Rossjohn J, Brenner MB, Gadola SD.
Eur J Immunol 2013-03-01
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Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.

Authors: Authors: Brennan PJ, Brigl M, Brenner MB.
Nat Rev Immunol 2013-02-01
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Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.

Authors: Authors: Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M.
Proc Natl Acad Sci U S A 2013-01-29
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