Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

Authors: Authors: Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB.
Nat Immunol 2013-01-01
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Arl13b regulates endocytic recycling traffic.

Authors: Authors: Barral DC, Garg S, Casalou C, Watts GF, Sandoval JL, Ramalho JS, Hsu VW, Brenner MB.
Proc Natl Acad Sci U S A 2012-12-26
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Aquaporin 2 promotes cell migration and epithelial morphogenesis.

Authors: Authors: Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA.
J Am Soc Nephrol 2012-09-01
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Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks.

Authors: Authors: Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ.
Nat Immunol 2012-04-01
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Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.

Authors: Authors: León L, Tatituri RV, Grenha R, Sun Y, Barral DC, Minnaard AJ, Bhowruth V, Veerapen N, Besra GS, Kasmar A, Peng W, Moody DB, Grabowski GA, Brenner MB.
Proc Natl Acad Sci U S A 2012-03-20
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Structural elucidation of diglycosyl diacylglycerol and monoglycosyl diacylglycerol from Streptococcus pneumoniae by multiple-stage linear ion-trap mass spectrometry with electrospray ionization.

Authors: Authors: Tatituri RV, Brenner MB, Turk J, Hsu FF.
J Mass Spectrom 2012-01-01
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Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement.

Authors: Authors: Noss EH, Chang SK, Watts GF, Brenner MB.
Arthritis Rheum 2011-12-01
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Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner.

Authors: Authors: King IL, Fortier A, Tighe M, Dibble J, Watts GF, Veerapen N, Haberman AM, Besra GS, Mohrs M, Brenner MB, Leadbetter EA.
Nat Immunol 2011-11-27
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Innate recognition of cell wall ß-glucans drives invariant natural killer T cell responses against fungi.

Authors: Authors: Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levitz SM, Brigl M, Brenner MB.
2011-11-17
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Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals.

Authors: Authors: Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB.
Nat Immunol 2011-10-30
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