Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.
Authors: Authors: Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB.
Immunity
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Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.
Authors: Authors: Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB.
J Exp Med
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Cadherin-11 regulates fibroblast inflammation.
Authors: Authors: Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB.
Proc Natl Acad Sci U S A
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Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration.
Authors: Authors: Gu Z, Noss EH, Hsu VW, Brenner MB.
J Cell Biol
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Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies.
Authors: Authors: Veerapen N, Leadbetter EA, Brenner MB, Cox LR, Besra GS.
Bioconjug Chem
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Regulation of CD1 antigen-presenting complex stability.
Authors: Authors: Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB.
J Biol Chem
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How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens.
Authors: Authors: Brigl M, Brenner MB.
Semin Immunol
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Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989.
Authors: Authors: Porcelli S, Brenner MB, Greenstein JL, Terhorst C, Balk SP, Bleicher PA.
J Immunol
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Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected].
Authors: Authors: Muindi K, Cernadas M, Watts GF, Royle L, Neville DC, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB.
Proc Natl Acad Sci U S A
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Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.
Authors: Authors: Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.
Arthritis Rheum
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