Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.
Authors: Authors: Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.
Arthritis Rheum
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Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11.
Authors: Authors: Chang SK, Gu Z, Brenner MB.
Immunol Rev
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Rapid and reliable generation of invariant natural killer T-cell lines in vitro.
Authors: Authors: Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB.
Immunology
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CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.
Authors: Authors: Felio K, Nguyen H, Dascher CC, Choi HJ, Li S, Zimmer MI, Colmone A, Moody DB, Brenner MB, Wang CR.
J Exp Med
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T cell responses in microbial infection.
Authors: Authors: Modlin RL, Brenner MB.
Curr Opin Immunol
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Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.
Authors: Authors: Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS.
Bioorg Med Chem Lett
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CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.
Authors: Authors: Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, Barral D, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB.
J Exp Med
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Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes.
Authors: Authors: Kiener HP, Niederreiter B, Lee DM, Jimenez-Boj E, Smolen JS, Brenner MB.
Arthritis Rheum
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Long-lasting molecular changes in human skin after repetitive in situ UV irradiation.
Authors: Authors: Brenner M, Coelho SG, Beer JZ, Miller SA, Wolber R, Smuda C, Hearing VJ.
J Invest Dermatol
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CD1a expression defines an interleukin-12 producing population of human dendritic cells.
Authors: Authors: Cernadas M, Lu J, Watts G, Brenner MB.
Clin Exp Immunol
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