Gary B. Ruvkun, Ph.D.
Professor of Genetics, Harvard Medical School
Department of Molecular Biology, Massachusetts General Hospital
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
A novel repeat domain that is often associated with RING finger and B-box motifs.
Heterochronic genes in development and evolution.
Aging, life span, and senescence.
Authors: Authors: Guarente L, Ruvkun G, Amasino R.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.
An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Authors: Authors: Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G.
Nature
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Nature
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The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.
Authors: Authors: Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G.
Genes Dev
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Genes Dev
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daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.