Gary B. Ruvkun, Ph.D.
Professor of Genetics, Harvard Medical School
Department of Molecular Biology, Massachusetts General Hospital
Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.
New motif in PBX genes.
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.
Authors: Authors: Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L.
Nature
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Nature
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Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
Authors: Authors: Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G.
Genes Dev
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Genes Dev
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Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
Nematode homeobox cluster.
Authors: Authors: Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH.
Nature
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Nature
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Regulation of transcription and cell identity by POU domain proteins.
Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.
The unc-86 gene product couples cell lineage and cell identity in C. elegans.
Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.