Gary B. Ruvkun, Ph.D.
Professor of Genetics, Harvard Medical School
Department of Molecular Biology, Massachusetts General Hospital
The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans.
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.
Authors: Authors: Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G.
PLoS Genet
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PLoS Genet
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Prediction of C. elegans longevity genes by human and worm longevity networks.
Authors: Authors: Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP.
PLoS One
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PLoS One
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Regulation of the C. elegans molt by pqn-47.
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
Authors: Authors: Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G.
PLoS Genet
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PLoS Genet
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The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
RNAi screening for fat regulatory genes with SRS microscopy.
Authors: Authors: Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS.
Nat Methods
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Nat Methods
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mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
Authors: Authors: Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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