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George Church, Ph.D.

617-432-7562
Church Lab Website
Inter-homologue repair in fertilized human eggs?
Authors: Authors: Egli D, Zuccaro MV, Kosicki M, Church GM, Bradley A, Jasin M.
Nature
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An enhanced CRISPR repressor for targeted mammalian gene regulation.
Authors: Authors: Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S, Church GM.
Nat Methods
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High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing.
Authors: Authors: de Paz AM, Cybulski TR, Marblestone AH, Zamft BM, Church GM, Boyden ES, Kording KP, Tyo KEJ.
Nucleic Acids Res
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Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.
Authors: Authors: Clarke R, Heler R, MacDougall MS, Yeo NC, Chavez A, Regan M, Hanakahi L, Church GM, Marraffini LA, Merrill BJ.
Mol Cell
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Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.
Authors: Authors: Musah S, Dimitrakakis N, Camacho DM, Church GM, Ingber DE.
Nat Protoc
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Building Capacity for a Global Genome Editing Observatory: Conceptual Challenges.
Authors: Authors: Hurlbut JB, Jasanoff S, Saha K, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, Kimes JP, Mills P, Moses J, Park BS, Parens E, Salzman R, Saxena A, Simmet H, Simoncelli T, Snead OC, Rajan KS, Truog RD, Williams P, Woopen C.
Trends Biotechnol
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High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast.
Authors: Authors: Guo X, Chavez A, Tung A, Chan Y, Kaas C, Yin Y, Cecchi R, Garnier SL, Kelsic ED, Schubert M, DiCarlo JE, Collins JJ, Church GM.
Nat Biotechnol
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Current CRISPR gene drive systems are likely to be highly invasive in wild populations.
Authors: Authors: Noble C, Adlam B, Church GM, Esvelt KM, Nowak MA.
Elife
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Characterizing Protein Kinase Substrate Specificity Using the Proteomic Peptide Library (ProPeL) Approach.
Authors: Authors: Lubner JM, Balsbaugh JL, Church GM, Chou MF, Schwartz D.
Curr Protoc Chem Biol
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Codon usage of highly expressed genes affects proteome-wide translation efficiency.
Authors: Authors: Frumkin I, Lajoie MJ, Gregg CJ, Hornung G, Church GM, Pilpel Y.
Proc Natl Acad Sci U S A
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