Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
Authors: Authors: Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR.
Science
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Science
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Highly efficient Cas9-mediated transcriptional programming.
Authors: Authors: Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM.
Nat Methods
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Nat Methods
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Precision Chemistry for Precision Medicine.
Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues.
Authors: Authors: Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Ferrante TC, Terry R, Turczyk BM, Yang JL, Lee HS, Aach J, Zhang K, Church GM.
Nat Protoc
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Nat Protoc
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Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics.
Authors: Authors: Yaung SJ, Deng L, Li N, Braff JL, Church GM, Bry L, Wang HH, Gerber GK.
Mol Syst Biol
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Mol Syst Biol
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Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells.
Authors: Authors: Byrne SM, Ortiz L, Mali P, Aach J, Church GM.
Nucleic Acids Res
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Nucleic Acids Res
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Biocontainment of genetically modified organisms by synthetic protein design.
Authors: Authors: Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville JE, Gregg CJ, Stoddard BL, Church GM.
Nature
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Nature
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Direct mutagenesis of thousands of genomic targets using microarray-derived oligonucleotides.
Authors: Authors: Bonde MT, Kosuri S, Genee HJ, Sarup-Lytzen K, Church GM, Sommer MO, Wang HH.
ACS Synth Biol
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ACS Synth Biol
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Insights into the evolution of longevity from the bowhead whale genome.
Authors: Authors: Keane M, Semeiks J, Webb AE, Li YI, Quesada V, Craig T, Madsen LB, van Dam S, Brawand D, Marques PI, Michalak P, Kang L, Bhak J, Yim HS, Grishin NV, Nielsen NH, Heide-Jørgensen MP, Oziolor EM, Matson CW, Church GM, Stuart GW, Patton JC, George JC, Suydam R, Larsen K, López-Otín C, O'Connell MJ, Bickham JW, Thomsen B, de Magalhães JP.
Cell Rep
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Cell Rep
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Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68.