George Church

George Church, Ph.D.

617-432-7562

Church Lab Website

Publications

oFlowSeq: a quantitative approach to identify protein coding mutations affecting cell type enrichment using mosaic CRISPR-Cas9 edited cerebral organoids.

Authors: Authors: Dawes P, Murray LF, Olson MN, Barton NJ, Smullen M, Suresh M, Yan G, Zhang Y, Fernandez-Fontaine A, English J, Uddin M, Pak C, Church GM, Chan Y, Lim ET.
Hum Genet 2023-08-01
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Fertility restoration in mice with chemotherapy induced ovarian failure using differentiated iPSCs.

Authors: Authors: Elias KM, Ng NW, Dam KU, Milne A, Disler ER, Gockley A, Holub N, Seshan ML, Church GM, Ginsburg ES, Anchan RM.
EBioMedicine 2023-08-01
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Mitigating age-related somatic mutation burden.

Authors: Authors: Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K.
Trends Mol Med 2023-07-01
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Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G.

Authors: Authors: Smullen M, Olson MN, Murray LF, Suresh M, Yan G, Dawes P, Barton NJ, Mason JN, Zhang Y, Fernandez-Fontaine AA, Church GM, Mastroeni D, Wang Q, Lim ET, Chan Y, Readhead B.
Sci Rep 2023-06-27
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CRISPR-mediated germline mutagenesis for genetic sterilization of Anopheles gambiae males.

Authors: Authors: Smidler AL, Paton DG, Church GM, Esvelt KM, Shaw WR, Catteruccia F.
bioRxiv 2023-06-13
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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity.

Authors: Authors: Dec E, Clement J, Cheng K, Church GM, Fossel MB, Rehkopf DH, Rosero-Bixby L, Kobor MS, Lin DT, Lu AT, Fei Z, Guo W, Chew YC, Yang X, Putra SED, Reiner AP, Correa A, Vilalta A, Pirazzini C, Passarino G, Monti D, Arosio B, Garagnani P, Franceschi C, Horvath S.
Geroscience 2023-06-01
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Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins.

Authors: Authors: Ter-Ovanesyan D, Gilboa T, Budnik B, Nikitina A, Whiteman S, Lazarovits R, Trieu W, Kalish D, Church GM, Walt DR.
Elife 2023-05-30
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Light and carbon: Synthetic biology toward new cyanobacteria-based living biomaterials.

Authors: Authors: Goodchild-Michelman IM, Church GM, Schubert MG, Tang TC.
Mater Today Bio 2023-04-01
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Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability.

Authors: Authors: Jo C, Zhang J, Tam JM, Church GM, Khalil AS, Segrè D, Tang TC.
Mater Today Bio 2023-04-01
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Correction: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression.

Authors: Authors: Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su AR, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GM.
Elife 2023-03-22
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