Jonathan G. Seidman

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School

617-432-7830

Publications

Left Ventricular Structural, Physiological, and Transcriptomic Abnormalities in a Novel Porcine Hypertrophic Cardiomyopathy Model.

Authors: Authors: Green EM, Rio CD, Shibbani K, Meyerholz DK, Gorham J, Kim S, DeLaughter DM, Henze MP, Rogers CS, Gifford LM, Kafa M, Rohret F, Goeken JA, McLendon JM, Boudreau RL, Seidman CE, Sieren JC, Weiss RM, Seidman JG, Divekar A, Ahmad F.
JACC Basic Transl Sci 2026-10-09
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Genetic Variants in Cardiomyopathy Genes Are Associated With Right Ventricular Dysfunction in Repaired Tetralogy of Fallot.

Authors: Authors: Bowen CJ, Ferreira F, Arora N, Avillach P, Brueckner M, Chung WK, Cnota JF, Gelb BD, Lewis MJ, Channing A, Liu C, Feldman HA, Roberts AE, Tristani-Firouzi M, Wagner M, Seidman JG, Seidman CE, Morton SU, Newburger JW, Geva T.
JACC Heart Fail 2026-10-08
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Mechanistic diversity within RLC-dependent myosin ATPase inhibitors differentiates EDG-7500, a diastolic-selective cardiac sarcomere modulator.

Authors: Authors: Emter CA, Henze M, DuVall M, Lehman S, Lee L, Barthel B, Hawryluk NA, Madden M, Wu Y, Perry A, Beyer M, Wei E, Rupert C, Roof S, Peter A, DiNatale E, Cantrell S, Tolley J, Schlachter S, van der Velden J, Michels M, Seidman C, Ma W, Leinwand L, Campbell S, Ochala J, Bluemke D, Tharp D, Seidman J, Del Rio CL, Semigran M, Evanchik M, Koch K, Russell A.
JCI Insight 2026-09-22
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The molecular landscape of hypertrophic cardiomyopathy across disease stages and genotypes.

Authors: Authors: Adami E, Kim Y, Zheng SL, Shvetsov N, Losert C, Maatz H, Barish S, Venturini G, Anguita NL, Shi Q, Neyazi M, Beyer M, Wei EQ, Adam A, Suresh A, Reichart D, Lindberg E, Brown KJ, Strohmenger V, Saul D, Gärtner A, Lee M, Mach L, Robertus JL, Gorham JM, Haas J, Liebig LA, Lippert C, Meder B, Myronova A, Patone G, Barnett SN, Ware JS, de Robertis F, Pantazis A, Gummert J, Viveiros A, Chen H, Ruiz-Orera J, Frey N, McDonough BA, Mitchell RN, Padera RF, Day SM, Ho CY, Lakdawala NK, Milting H, Heinig M, Oudit GY, Noseda M, Seidman JG, Hübner N, Seidman CE.
Sci Transl Med 2026-09-16
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Apelin analog treatment reverses severe pulmonary arterial hypertension and right ventricular heart failure.

Authors: Authors: Vu J, Zhabyeyev P, Brown KJ, Gorham J, DeLaughter DM, Chen H, Jayawardena TU, Vergara A, Alexiou M, Wijewardane A, Fischer C, Avet C, Ewasiuk A, Wang F, Chappell MC, Kim Y, Bouvier M, Vederas JC, Seidman CE, Seidman JG, Oudit GY.
JCI Insight 2026-08-10
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Uniparental Disomy Reveals Hidden Genetic Causes of Congenital Heart Disease.

Authors: Authors: Kong N, Abello J, Yoon CJ, Ruttenberg A, Li Z, Richee J, Colijn S, Bowling KM, Wilke MVMB, Dong W, Ng K, Mehinovic E, Patel P, DePalma SR, Wang YC, Wijerathne TD, Lacroix JJ, Zhao Y, Sah R, Nourse JL, Pathak M, Ensing J, Grainger S, Yost HJ, Tristani-Firouzi M, Wagner M, Ollberding NJ, Seidman J, Morton SU, Gelb BD, Chung WK, Lifton RP, Sun Y, Edwards JR, Dutcher S, Seidman CE, Griffith OL, Griffith M, Schedl T, Lek M, Brueckner M, Stratman AN, Jin SC.
Res Sq 2026-07-20
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Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.

Authors: Authors: Dutta D, Kim Y, Ho CY, Seidman JG, Seidman CE, Craig R, Padrón R.
Proc Natl Acad Sci U S A 2026-07-07
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Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy.

Authors: Authors: Pfaller AT, Veneziano C, Murthi SR, Stöckl JB, Shashikadze B, Flenkenthaler F, Gorham J, Moretti A, Kitanovic A, Gearing LJ, Heinrich F, Durek P, Lehmann K, Mashreghi MF, Ewert P, Fröhlich T, Schmitt JP, Spielmann N, Hrabe de Angelis M, Schmid M, Toepfer CN, Latz E, Klingel K, Santamaria G, Seidman JG, Seidman CE, Wolf CM.
JACC Basic Transl Sci 2026-07-01
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Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis.

Authors: Authors: Neyazi M, Venturini G, Brown KJ, Choi Y, Gorham JM, Layton OG, Verma A, Wang AJ, Gross RT, McDonough BA, Mendiola Pla M, Viveiros A, DeLaughter DM, DePalma SR, Kim Y, Reichart D, Wakimoto H, Elledge SJ, Divakaran S, Mitchell RN, Koh J, Park JB, Bowles DE, Glass C, Oudit GY, Seidman JG, Seidman CE.
Circulation 2026-05-28
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Rare KDR Variants Define a Distinct Genetic Contribution to Congenital Heart Disease.

Authors: Authors: Ladha FA, Avillach P, Opotowsky AR, Nael A, Brueckner M, Chung WK, Cnota JF, Gelb BD, Lewis M, Liu C, Roberts AE, Seidman CE, Seidman JG, Tristani-Firouzi M, Wagner M, Newburger JW, Kim Y, Morton SU.
Circ Genom Precis Med 2026-04-22
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