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Jonathan G. Seidman, Ph.D.
Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics
Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling.
Authors: Authors: Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A.
Int J Mol Sci
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Structural variation across 138,134 samples in the TOPMed consortium.
Authors: Authors: Jun G, English A, Metcalf G, Yang J, Chaisson M, Pankratz N, Menon V, Salerno W, Krasheninina O, Smith A, Lane J, Blackwell T, Kang HM, Salvi S, Meng Q, Shen H, Pasham D, Bhamidipati S, Kottapalli K, Arnett D, Ashley-Koch A, Auer P, Beutel K, Bis J, Blangero J, Bowden D, Brody J, Cade B, Chen YI, Cho M, Curran J, Fornage M, Frredman B, Fingerlin T, Gelb B, Hou L, Hung YJ, Kane JP, Kaplan R, Kim W, Loos R, Marcus G, Mathias R, McGarvey S, Montgomery C, Naseri T, Nouraie S, Preuss M, Palmer N, Peyser P, Raffield L, Ratan A, Redline S, Reupena M, Rotter J, Rich S, Rienstra M, Ruczinski I, Sankaran V, Schwartz D, Seidman C, Seidman J, Silverman E, Smith J, Stilp A, Taylor K, Telen M, Weiss S, Williams LK, Wu B, Yanek L, Zhang Y, Lasky-Su J, Gingras MC, Dutcher S, Eichler E, Gabriel S, Germer S, Kim R, Martinez K, Nickerson D, Luo J, Reiner A, Gibbs R, Boerwinkle E, Abecasis G, Sedlazeck F.
Res Sq
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Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice.
Authors: Authors: Reichart D, Newby GA, Wakimoto H, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JDC, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C.
Nat Med
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mTOR signaling inhibition decreases lysosome migration and impairs the success of Trypanosoma cruzi infection and replication in cardiomyocytes.
Authors: Authors: Alvim JM, Venturini G, Oliveira TGM, Seidman JG, Seidman CE, Krieger JE, Pereira AC.
Acta Trop
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Structural variation across 138,134 samples in the TOPMed consortium.
Authors: Authors: Jun G, English AC, Metcalf GA, Yang J, Chaisson MJ, Pankratz N, Menon VK, Salerno WJ, Krasheninina O, Smith AV, Lane JA, Blackwell T, Kang HM, Salvi S, Meng Q, Shen H, Pasham D, Bhamidipati S, Kottapalli K, Arnett DK, Ashley-Koch A, Auer PL, Beutel KM, Bis JC, Blangero J, Bowden DW, Brody JA, Cade BE, Chen YI, Cho MH, Curran JE, Fornage M, Freedman BI, Fingerlin T, Gelb BD, Hou L, Hung YJ, Kane JP, Kaplan R, Kim W, Loos RJF, Marcus GM, Mathias RA, McGarvey ST, Montgomery C, Naseri T, Nouraie SM, Preuss MH, Palmer ND, Peyser PA, Raffield LM, Ratan A, Redline S, Reupena S, Rotter JI, Rich SS, Rienstra M, Ruczinski I, Sankaran VG, Schwartz DA, Seidman CE, Seidman JG, Silverman EK, Smith JA, Stilp A, Taylor KD, Telen MJ, Weiss ST, Williams LK, Wu B, Yanek LR, Zhang Y, Lasky-Su J, Gingras MC, Dutcher SK, Eichler EE, Gabriel S, Germer S, Kim R, Viaud-Martinez KA, Nickerson DA, Luo J, Reiner A, Gibbs RA, Boerwinkle E, Abecasis G, Sedlazeck FJ.
bioRxiv
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Loss of epigenetic information as a cause of mammalian aging.
Authors: Authors: Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA.
Cell
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Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation.
Authors: Authors: Venturini G, Alvim JM, Padilha K, Toepfer CN, Gorham JM, Wasson LK, Biagi D, Schenkman S, Carvalho VM, Salgueiro JS, Cardozo KHM, Krieger JE, Pereira AC, Seidman JG, Seidman CE.
Front Cell Infect Microbiol
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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy.
Authors: Authors: Margara F, Psaras Y, Wang ZJ, Schmid M, Doste R, Garfinkel AC, Repetti GG, Seidman JG, Seidman CE, Rodriguez B, Toepfer CN, Bueno-Orovio A.
Sci Rep
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An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
Authors: Authors: Quiat D, Kim SW, Zhang Q, Morton SU, Pereira AC, DePalma SR, Willcox JAL, McDonough B, DeLaughter DM, Gorham JM, Curran JJ, Tumblin M, Nicolau Y, Artunduaga MA, Quintanilla-Dieck L, Osorno G, Serrano L, Hamdan U, Eavey RD, Seidman CE, Seidman JG.
Proc Natl Acad Sci U S A
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Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: a UK Biobank Analysis.
Authors: Authors: Hylind RJ, Pereira AC, Quiat D, Chandler SF, Roston TM, Pu WT, Bezzerides VJ, Seidman JG, Seidman CE, Abrams DJ.
Circ Genom Precis Med
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