Jonathan Seidman headshot

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling.
Authors: Authors: Ewoldt JK, Wang MC, McLellan MA, Cloonan PE, Chopra A, Gorham J, Li L, DeLaughter DM, Gao X, Lee JH, Willcox JAL, Layton O, Luu RJ, Toepfer CN, Eyckmans J, Seidman CE, Seidman JG, Chen CS.
Sci Adv
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An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury.
Authors: Authors: Fleischer S, Nash TR, Tamargo MA, Lock RI, Venturini G, Morsink M, Graney PL, Li V, Lamberti MJ, Liberman M, Kim Y, Tavakol DN, Zhuang RZ, Whitehead J, Friedman RA, Soni RK, Seidman JG, Seidman CE, Geraldino-Pardilla L, Winchester R, Vunjak-Novakovic G.
Nat Cardiovasc Res
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Predictive Modeling of Endocardial Fibroelastosis Recurrence in Patients with Congenital Heart Disease.
Authors: Authors: Diaz-Gil D, Silva-Gomez N, Morton SU, Seidman JG, Seidman CE, Zurakowski D, Staffa SJ, Marx GR, Emani SM, Del Nido PJ, Friehs I.
J Thorac Cardiovasc Surg
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Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated SMAD2 mutations.
Authors: Authors: Bhattacharya R, Ward T, Kalejaiye TD, Mishra A, Leeman S, Arzaghi H, Seidman JG, Seidman CE, Musah S.
bioRxiv
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Increased endothelial sclerostin caused by elevated DSCAM mediates multiple trisomy 21 phenotypes.
Authors: Authors: McKean DM, Zhang Q, Narayan P, Morton SU, Strohmenger V, Tang VT, McAllister S, Sharma A, Quiat D, Reichart D, DeLaughter DM, Wakimoto H, Gorham JM, Brown K, McDonough B, Willcox JA, Jang MY, DePalma SR, Ward T, Kim R, Cleveland JD, Seidman JG, Seidman CE.
J Clin Invest
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Endocardial primary cilia and blood flow are required for regulation of EndoMT during endocardial cushion development.
Authors: Authors: Berg K, Gorham J, Lundt F, Seidman J, Brueckner M.
bioRxiv
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Genome Sequencing is Critical for Forecasting Outcomes following Congenital Cardiac Surgery.
Authors: Authors: Watkins WS, Hernandez EJ, Miller TA, Blue NR, Zimmerman R, Griffiths ER, Frise E, Bernstein D, Boskovski MT, Brueckner M, Chung WK, Gaynor JW, Gelb BD, Goldmuntz E, Gruber PJ, Newburger JW, Roberts AE, Morton SU, Mayer JE, Seidman CE, Seidman JG, Shen Y, Wagner M, Yost HJ, Yandell M, Tristani-Firouzi M.
medRxiv
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CHD4 and SMYD1 repress common transcriptional programs in the developing heart.
Authors: Authors: Shi W, Wasson LK, Dorr KM, Robbe ZL, Wilczewski CM, Hepperla AJ, Davis IJ, Seidman CE, Seidman JG, Conlon FL.
Development
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An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury.
Authors: Authors: Fleischer S, Nash TR, Tamargo MA, Lock RI, Venturini G, Morsink M, Li V, Lamberti MJ, Graney PL, Liberman M, Kim Y, Zhuang RZ, Whitehead J, Friedman RA, Soni RK, Seidman JG, Seidman CE, Geraldino-Pardilla L, Winchester R, Vunjak-Novakovic G.
bioRxiv
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Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution.
Authors: Authors: Chen J, Zhang X, DeLaughter DM, Trembley MA, Saifee S, Xiao F, Chen J, Zhou P, Seidman CE, Seidman JG, Pu WT.
Circ Res
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