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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
Mechanistic diversity within RLC-dependent myosin ATPase inhibitors differentiates EDG-7500, a diastolic-selective cardiac sarcomere modulator.
Authors: Authors: Emter CA, Henze M, DuVall M, Lehman S, Lee L, Barthel B, Hawryluk NA, Madden M, Wu Y, Perry A, Beyer M, Wei E, Rupert C, Roof S, Peter A, DiNatale E, Cantrell S, Tolley J, Schlachter S, van der Velden J, Michels M, Seidman C, Ma W, Leinwand L, Campbell S, Ochala J, Bluemke D, Tharp D, Seidman J, Del Rio CL, Semigran M, Evanchik M, Koch K, Russell A.
JCI Insight
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The molecular landscape of hypertrophic cardiomyopathy across disease stages and genotypes.
Authors: Authors: Adami E, Kim Y, Zheng SL, Shvetsov N, Losert C, Maatz H, Barish S, Venturini G, Anguita NL, Shi Q, Neyazi M, Beyer M, Wei EQ, Adam A, Suresh A, Reichart D, Lindberg E, Brown KJ, Strohmenger V, Saul D, Gärtner A, Lee M, Mach L, Robertus JL, Gorham JM, Haas J, Liebig LA, Lippert C, Meder B, Myronova A, Patone G, Barnett SN, Ware JS, de Robertis F, Pantazis A, Gummert J, Viveiros A, Chen H, Ruiz-Orera J, Frey N, McDonough BA, Mitchell RN, Padera RF, Day SM, Ho CY, Lakdawala NK, Milting H, Heinig M, Oudit GY, Noseda M, Seidman JG, Hübner N, Seidman CE.
Sci Transl Med
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Apelin analog treatment reverses severe pulmonary arterial hypertension and right ventricular heart failure.
Authors: Authors: Vu J, Zhabyeyev P, Brown KJ, Gorham J, DeLaughter DM, Chen H, Jayawardena TU, Vergara A, Alexiou M, Wijewardane A, Fischer C, Avet C, Ewasiuk A, Wang F, Chappell MC, Kim Y, Bouvier M, Vederas JC, Seidman CE, Seidman JG, Oudit GY.
JCI Insight
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Uniparental Disomy Reveals Hidden Genetic Causes of Congenital Heart Disease.
Authors: Authors: Kong N, Abello J, Yoon CJ, Ruttenberg A, Li Z, Richee J, Colijn S, Bowling KM, Wilke MVMB, Dong W, Ng K, Mehinovic E, Patel P, DePalma SR, Wang YC, Wijerathne TD, Lacroix JJ, Zhao Y, Sah R, Nourse JL, Pathak M, Ensing J, Grainger S, Yost HJ, Tristani-Firouzi M, Wagner M, Ollberding NJ, Seidman J, Morton SU, Gelb BD, Chung WK, Lifton RP, Sun Y, Edwards JR, Dutcher S, Seidman CE, Griffith OL, Griffith M, Schedl T, Lek M, Brueckner M, Stratman AN, Jin SC.
Res Sq
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Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.
Authors: Authors: Dutta D, Kim Y, Ho CY, Seidman JG, Seidman CE, Craig R, Padrón R.
Proc Natl Acad Sci U S A
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Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy.
Authors: Authors: Pfaller AT, Veneziano C, Murthi SR, Stöckl JB, Shashikadze B, Flenkenthaler F, Gorham J, Moretti A, Kitanovic A, Gearing LJ, Heinrich F, Durek P, Lehmann K, Mashreghi MF, Ewert P, Fröhlich T, Schmitt JP, Spielmann N, Hrabe de Angelis M, Schmid M, Toepfer CN, Latz E, Klingel K, Santamaria G, Seidman JG, Seidman CE, Wolf CM.
JACC Basic Transl Sci
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Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis.
Authors: Authors: Neyazi M, Venturini G, Brown KJ, Choi Y, Gorham JM, Layton OG, Verma A, Wang AJ, Gross RT, McDonough BA, Mendiola Pla M, Viveiros A, DeLaughter DM, DePalma SR, Kim Y, Reichart D, Wakimoto H, Elledge SJ, Divakaran S, Mitchell RN, Koh J, Park JB, Bowles DE, Glass C, Oudit GY, Seidman JG, Seidman CE.
Circulation
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Rare KDR Variants Define a Distinct Genetic Contribution to Congenital Heart Disease.
Authors: Authors: Ladha FA, Avillach P, Opotowsky AR, Nael A, Brueckner M, Chung WK, Cnota JF, Gelb BD, Lewis M, Liu C, Roberts AE, Seidman CE, Seidman JG, Tristani-Firouzi M, Wagner M, Newburger JW, Kim Y, Morton SU.
Circ Genom Precis Med
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ROBO2 Variants Associated With Atrial Septal Defect Define a Novel Regulatory Element.
Authors: Authors: Kim SW, Parfenov M, Rodriguez-Murillo L, Conner DA, Sharma A, Peter I, Xiao F, Layton O, Tai A, Ward T, Wasson LK, Gorham JM, Mazaika E, Lagomarsino VN, Young-Pearse TL, Goldmuntz E, Wakimoto H, Agopian AJ, McKean DM, DePalma SR, Pu WT, Seidman CE, Gelb BD, Seidman JG.
Circ Genom Precis Med
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Cell shape and maturation impacts a-actinin-2 tension in iPSC-derived cardiomyocytes.
Authors: Authors: Dutta PK, Toth JM, Sundaram S, Chen X, Chopra A, Ewoldt JK, Cloonan P, Gao X, LaCroix AS, Hoffman BD, Shenoy VB, Seidman CE, Seidman JG, Chen CS, Eyckmans J.
APL Bioeng
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