Jonathan G. Seidman

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School

617-432-7830

Publications

Cell shape and maturation impacts a-actinin-2 tension in iPSC-derived cardiomyocytes.

Authors: Authors: Dutta PK, Toth JM, Sundaram S, Chen X, Chopra A, Ewoldt JK, Cloonan P, Gao X, LaCroix AS, Hoffman BD, Shenoy VB, Seidman CE, Seidman JG, Chen CS, Eyckmans J.
APL Bioeng 2026-03-01
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Titin-related familial dilated cardiomyopathy: factors associated with disease onset.

Authors: Authors: Johnson R, Fletcher RA, Peters S, Ohanian M, Soka M, Smolnikov A, Abihider KE, Ackerman MJ, Ader F, Akhtar MM, Amin AS, Ashley EA, Atherton JJ, Austin R, Baas AF, Bagnall RD, Ross SB, Blouin JL, Brown EE, Bundgaard H, Cannie D, Chmielewski P, Correnti G, Crespo-Leiro MG, Dal Ferro M, Dellefave-Castillo LM, Dominguez F, Dooijes D, Dybro AM, Ed Demri Y, El Hachmi M, Escobar-Lopez L, Foye SJ, Franaszczyk M, Gigli M, Lopez EG, Goudal A, Graw S, Guipponi M, Haan E, Haas J, Hammersley DJ, Hansen FG, Hayward CS, Hey TM, Heymans S, Ho CY, Houweling AC, Ingles J, Ingrey A, Jabbour A, James PA, Jansweijer JA, Jongbloed JDH, Keogh AM, Larrañaga-Moreira JM, Lekanne Deprez RH, Macciocca I, Macdonald PS, Mansencal N, Mansour J, Martinez-Veira C, McDonough B, McGaughran J, Medo K, Merlo M, Michalak E, Monserrat L, Mountain H, Muller SA, Murphy AM, Murray B, Oates EC, Ormondroyd E, Pachter N, Paldino A, Palmyre A, Pereira NL, Picard KC, Poplawski N, Prasad S, Proukhnitzky J, Pruny JF, Reant P, Richard P, Ronan A, Sedaghat-Hamedani F, Semsarian C, Storm G, Stroeks S, Syrris P, Taylor MRG, Thomson K, Thompson T, van Tintelen JP, Vissing CR, Waddell-Smith KE, Wallis M, Zentner D, Arnott C, Marian AJ, Oh J, Fokstuen S, James CA, Barriales-Villa R, Meder B, Wahbi K, Giudicessi JR, Parikh VN, Ware JS, Piriou N, Rooryck C, Lakdawala NK, Mestroni L, Sinagra G, Elliott PM, Watkins H, McNally EM, Charron P, van Spaendonck-Zwarts KY, Garcia-Pavia P, Peña-Peña ML, Mogensen J, Christensen AH, Bilinska ZT, Rasmussen TB, Seidman JG, Seidman CE, Te Riele ASJM, Verdonschot JAJ, Pinto YM, Christiaans I, Fatkin D.
Eur Heart J 2025-12-22
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Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.

Authors: Authors: Bhattacharya R, Ward T, Kalejaiye TD, Mishra A, Leeman SM, Arzaghi H, Seidman JG, Seidman CE, Musah S.
Nat Biomed Eng 2025-11-03
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Endocardial primary cilia and blood flow regulate EndoMT during endocardial cushion development.

Authors: Authors: Berg K, Gorham J, Lundt F, Seidman J, Brueckner M.
Nat Cardiovasc Res 2025-09-01
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Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy.

Authors: Authors: Wang YJ, Singh K, Lokman AB, Deng S, Sunitha B, Coelho Lima J, Beglov J, Kelly M, Blease A, Fung JCK, Huang A, Attar M, Stork LA, Maguire ML, Schneider JE, Marston SB, Soilleux EJ, Dendrou CA, Coles M, Buckley CD, Seidman JG, Seidman CE, Redwood C, Ashrafian H, Watkins H.
Sci Transl Med 2025-07-09
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GLP1R upregulation in mitral regurgitation observed at a single nucleus level.

Authors: Authors: Tiwari S, Beyer M, Aranki SF, Neyazi M, Oudit GY, Layton O, Seidman JG, Seidman CE, Muehlschlegel JD.
J Mol Cell Cardiol 2025-06-01
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Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model.

Authors: Authors: Baka T, Moore J, Qin F, Yurista SR, Zhang A, He H, Chambers JM, Croteau D, Goel RK, Smith H, Wang MC, Chen CS, Hobai IA, Rombaldova M, Kuda O, Tardiff JC, Balschi JA, Pimentel DR, Seidman CE, Seidman JG, Emili A, Colucci WS, Luptak I.
Eur Heart J 2025-05-21
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Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.

Authors: Authors: Pepin ME, Konrad PJM, Nazir S, Bazgir F, Maack C, Nickel A, Gorman J, Hohl M, Schreiter F, Dewenter M, de Britto Chaves Filho A, Schulze A, Karlstaedt A, Frey N, Seidman C, Seidman J, Backs J.
Circ Res 2025-05-09
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BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury.

Authors: Authors: Ruan W, Li T, Bang IH, Lee J, Deng W, Ma X, Luo C, Du F, Yoo SH, Kim B, Li J, Yuan X, Figarella K, An YA, Wang YY, Liang Y, DeBerge M, Zhang D, Zhou Z, Wang Y, Gorham JM, Seidman JG, Seidman CE, Aranki SF, Nair R, Li L, Narula J, Zhao Z, Gorfe AA, Muehlschlegel JD, Tsai KL, Eltzschig HK.
Nature 2025-05-01
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Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.

Authors: Authors: Sierant MC, Jin SC, Bilguvar K, Morton SU, Dong W, Jiang W, Lu Z, Li B, López-Giráldez F, Tikhonova I, Zeng X, Lu Q, Choi J, Zhang J, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Sedore SC, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, King E, Wagner M, Srivastava D, Shen Y, Bernstein D, Porter GA, Newburger JW, Seidman JG, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Chung WK, Gelb BD, Seidman CE, Brueckner M, Lifton RP.
Proc Natl Acad Sci U S A 2025-04-01
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