Jonathan G. Seidman

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School

617-432-7830

Publications

Apelin analog treatment reverses severe pulmonary arterial hypertension and right ventricular heart failure.

Authors: Authors: Vu J, Zhabyeyev P, Brown KJ, Gorham J, DeLaughter DM, Chen H, Jayawardena TU, Vergara A, Alexiou M, Wijewardane A, Fischer C, Avet C, Ewasiuk A, Wang F, Chappell MC, Kim Y, Bouvier M, Vederas JC, Seidman CE, Seidman JG, Oudit GY.
JCI Insight 2026-08-10
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Uniparental Disomy Reveals Hidden Genetic Causes of Congenital Heart Disease.

Authors: Authors: Kong N, Abello J, Yoon CJ, Ruttenberg A, Li Z, Richee J, Colijn S, Bowling KM, Wilke MVMB, Dong W, Ng K, Mehinovic E, Patel P, DePalma SR, Wang YC, Wijerathne TD, Lacroix JJ, Zhao Y, Sah R, Nourse JL, Pathak M, Ensing J, Grainger S, Yost HJ, Tristani-Firouzi M, Wagner M, Ollberding NJ, Seidman J, Morton SU, Gelb BD, Chung WK, Lifton RP, Sun Y, Edwards JR, Dutcher S, Seidman CE, Griffith OL, Griffith M, Schedl T, Lek M, Brueckner M, Stratman AN, Jin SC.
Res Sq 2026-07-20
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Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.

Authors: Authors: Dutta D, Kim Y, Ho CY, Seidman JG, Seidman CE, Craig R, Padrón R.
Proc Natl Acad Sci U S A 2026-07-07
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Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy.

Authors: Authors: Pfaller AT, Veneziano C, Murthi SR, Stöckl JB, Shashikadze B, Flenkenthaler F, Gorham J, Moretti A, Kitanovic A, Gearing LJ, Heinrich F, Durek P, Lehmann K, Mashreghi MF, Ewert P, Fröhlich T, Schmitt JP, Spielmann N, Hrabe de Angelis M, Schmid M, Toepfer CN, Latz E, Klingel K, Santamaria G, Seidman JG, Seidman CE, Wolf CM.
JACC Basic Transl Sci 2026-07-01
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Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis.

Authors: Authors: Neyazi M, Venturini G, Brown KJ, Choi Y, Gorham JM, Layton OG, Verma A, Wang AJ, Gross RT, McDonough BA, Mendiola Pla M, Viveiros A, DeLaughter DM, DePalma SR, Kim Y, Reichart D, Wakimoto H, Elledge SJ, Divakaran S, Mitchell RN, Koh J, Park JB, Bowles DE, Glass C, Oudit GY, Seidman JG, Seidman CE.
Circulation 2026-05-28
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Rare KDR Variants Define a Distinct Genetic Contribution to Congenital Heart Disease.

Authors: Authors: Ladha FA, Avillach P, Opotowsky AR, Nael A, Brueckner M, Chung WK, Cnota JF, Gelb BD, Lewis M, Liu C, Roberts AE, Seidman CE, Seidman JG, Tristani-Firouzi M, Wagner M, Newburger JW, Kim Y, Morton SU.
Circ Genom Precis Med 2026-04-22
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ROBO2 Variants Associated With Atrial Septal Defect Define a Novel Regulatory Element.

Authors: Authors: Kim SW, Parfenov M, Rodriguez-Murillo L, Conner DA, Sharma A, Peter I, Xiao F, Layton O, Tai A, Ward T, Wasson LK, Gorham JM, Mazaika E, Lagomarsino VN, Young-Pearse TL, Goldmuntz E, Wakimoto H, Agopian AJ, McKean DM, DePalma SR, Pu WT, Seidman CE, Gelb BD, Seidman JG.
Circ Genom Precis Med 2026-04-01
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Cell shape and maturation impacts a-actinin-2 tension in iPSC-derived cardiomyocytes.

Authors: Authors: Dutta PK, Toth JM, Sundaram S, Chen X, Chopra A, Ewoldt JK, Cloonan P, Gao X, LaCroix AS, Hoffman BD, Shenoy VB, Seidman CE, Seidman JG, Chen CS, Eyckmans J.
APL Bioeng 2026-03-01
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Deep-learning analysis of 3D microarchitectural remodeling in hypertrophic cardiomyopathy.

Authors: Authors: Wei EQ, Beyer M, Brown KJ, Bansbach AJ, Gorham JM, McDonough B, Chen H, Khoramjoo M, Zhang A, Bishop B, Ahmad F, Del Rio C, Chang CP, Ryba DM, Day SM, Fatkin D, Oudit GY, Seidman CE, Seidman JG.
Science 2026-01-15
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Titin-related familial dilated cardiomyopathy: factors associated with disease onset.

Authors: Authors: Johnson R, Fletcher RA, Peters S, Ohanian M, Soka M, Smolnikov A, Abihider KE, Ackerman MJ, Ader F, Akhtar MM, Amin AS, Ashley EA, Atherton JJ, Austin R, Baas AF, Bagnall RD, Ross SB, Blouin JL, Brown EE, Bundgaard H, Cannie D, Chmielewski P, Correnti G, Crespo-Leiro MG, Dal Ferro M, Dellefave-Castillo LM, Dominguez F, Dooijes D, Dybro AM, Ed Demri Y, El Hachmi M, Escobar-Lopez L, Foye SJ, Franaszczyk M, Gigli M, Lopez EG, Goudal A, Graw S, Guipponi M, Haan E, Haas J, Hammersley DJ, Hansen FG, Hayward CS, Hey TM, Heymans S, Ho CY, Houweling AC, Ingles J, Ingrey A, Jabbour A, James PA, Jansweijer JA, Jongbloed JDH, Keogh AM, Larrañaga-Moreira JM, Lekanne Deprez RH, Macciocca I, Macdonald PS, Mansencal N, Mansour J, Martinez-Veira C, McDonough B, McGaughran J, Medo K, Merlo M, Michalak E, Monserrat L, Mountain H, Muller SA, Murphy AM, Murray B, Oates EC, Ormondroyd E, Pachter N, Paldino A, Palmyre A, Pereira NL, Picard KC, Poplawski N, Prasad S, Proukhnitzky J, Pruny JF, Reant P, Richard P, Ronan A, Sedaghat-Hamedani F, Semsarian C, Storm G, Stroeks S, Syrris P, Taylor MRG, Thomson K, Thompson T, van Tintelen JP, Vissing CR, Waddell-Smith KE, Wallis M, Zentner D, Arnott C, Marian AJ, Oh J, Fokstuen S, James CA, Barriales-Villa R, Meder B, Wahbi K, Giudicessi JR, Parikh VN, Ware JS, Piriou N, Rooryck C, Lakdawala NK, Mestroni L, Sinagra G, Elliott PM, Watkins H, McNally EM, Charron P, van Spaendonck-Zwarts KY, Garcia-Pavia P, Peña-Peña ML, Mogensen J, Christensen AH, Bilinska ZT, Rasmussen TB, Seidman JG, Seidman CE, Te Riele ASJM, Verdonschot JAJ, Pinto YM, Christiaans I, Fatkin D.
Eur Heart J 2025-12-22
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