Jonathan Seidman headshot

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.
Authors: Authors: Bhattacharya R, Ward T, Kalejaiye TD, Mishra A, Leeman SM, Arzaghi H, Seidman JG, Seidman CE, Musah S.
Nat Biomed Eng
View full abstract on Pubmed
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations.
Authors: Authors: Huang H, Wang Y, Zsengeller ZK, Gorham JM, Vemireddy V, Clark AJ, Pan H, Dreyfuss JM, Jotwani V, Shlipak MG, Sarnak MJ, Parikh CR, Thiessen-Philbrook H, Katz R, Waikar SS, Lake NJ, Lek M, Shi W, Puiu D, Hong YS, Seidman JG, Arking DE, Parikh SM.
Science
View full abstract on Pubmed
Endocardial primary cilia and blood flow regulate EndoMT during endocardial cushion development.
Authors: Authors: Berg K, Gorham J, Lundt F, Seidman J, Brueckner M.
Nat Cardiovasc Res
View full abstract on Pubmed
Enrichment of tandem repeat element variants near CHD genes identified by short- and long-read genome sequencing.
Authors: Authors: Suresh A, Morton SU, Quiat D, DePalma SR, Gorham JM, Brueckner M, Tristani-Firouzi M, Gelb BD, Seidman JG, Seidman CE.
BMC Med Genomics
View full abstract on Pubmed
Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery.
Authors: Authors: Watkins WS, Hernandez EJ, Miller TA, Blue NR, Zimmerman RM, Griffiths ER, Frise E, Bernstein D, Boskovski MT, Brueckner M, Chung WK, Gaynor JW, Gelb BD, Goldmuntz E, Gruber PJ, Newburger JW, Roberts AE, Morton SU, Mayer JE, Seidman CE, Seidman JG, Shen Y, Wagner M, Yost HJ, Yandell M, Tristani-Firouzi M.
Nat Commun
View full abstract on Pubmed
Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy.
Authors: Authors: Wang YJ, Singh K, Lokman AB, Deng S, Sunitha B, Coelho Lima J, Beglov J, Kelly M, Blease A, Fung JCK, Huang A, Attar M, Stork LA, Maguire ML, Schneider JE, Marston SB, Soilleux EJ, Dendrou CA, Coles M, Buckley CD, Seidman JG, Seidman CE, Redwood C, Ashrafian H, Watkins H.
Sci Transl Med
View full abstract on Pubmed
GLP1R upregulation in mitral regurgitation observed at a single nucleus level.
Authors: Authors: Tiwari S, Beyer M, Aranki SF, Neyazi M, Oudit GY, Layton O, Seidman JG, Seidman CE, Muehlschlegel JD.
J Mol Cell Cardiol
View full abstract on Pubmed
Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model.
Authors: Authors: Baka T, Moore J, Qin F, Yurista SR, Zhang A, He H, Chambers JM, Croteau D, Goel RK, Smith H, Wang MC, Chen CS, Hobai IA, Rombaldova M, Kuda O, Tardiff JC, Balschi JA, Pimentel DR, Seidman CE, Seidman JG, Emili A, Colucci WS, Luptak I.
Eur Heart J
View full abstract on Pubmed
Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.
Authors: Authors: Pepin ME, Konrad PJM, Nazir S, Bazgir F, Maack C, Nickel A, Gorman J, Hohl M, Schreiter F, Dewenter M, de Britto Chaves Filho A, Schulze A, Karlstaedt A, Frey N, Seidman C, Seidman J, Backs J.
Circ Res
View full abstract on Pubmed
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury.
Authors: Authors: Ruan W, Li T, Bang IH, Lee J, Deng W, Ma X, Luo C, Du F, Yoo SH, Kim B, Li J, Yuan X, Figarella K, An YA, Wang YY, Liang Y, DeBerge M, Zhang D, Zhou Z, Wang Y, Gorham JM, Seidman JG, Seidman CE, Aranki SF, Nair R, Li L, Narula J, Zhao Z, Gorfe AA, Muehlschlegel JD, Tsai KL, Eltzschig HK.
Nature
View full abstract on Pubmed