Jonathan G. Seidman

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School

617-432-7830

Publications

Deep-learning analysis of 3D microarchitectural remodeling in hypertrophic cardiomyopathy.

Authors: Authors: Wei EQ, Beyer M, Brown KJ, Bansbach AJ, Gorham JM, McDonough B, Chen H, Khoramjoo M, Zhang A, Bishop B, Ahmad F, Del Rio C, Chang CP, Ryba DM, Day SM, Fatkin D, Oudit GY, Seidman CE, Seidman JG.
Science 2026-01-15
View full abstract on Pubmed

Titin-related familial dilated cardiomyopathy: factors associated with disease onset.

Authors: Authors: Johnson R, Fletcher RA, Peters S, Ohanian M, Soka M, Smolnikov A, Abihider KE, Ackerman MJ, Ader F, Akhtar MM, Amin AS, Ashley EA, Atherton JJ, Austin R, Baas AF, Bagnall RD, Ross SB, Blouin JL, Brown EE, Bundgaard H, Cannie D, Chmielewski P, Correnti G, Crespo-Leiro MG, Dal Ferro M, Dellefave-Castillo LM, Dominguez F, Dooijes D, Dybro AM, Ed Demri Y, El Hachmi M, Escobar-Lopez L, Foye SJ, Franaszczyk M, Gigli M, Lopez EG, Goudal A, Graw S, Guipponi M, Haan E, Haas J, Hammersley DJ, Hansen FG, Hayward CS, Hey TM, Heymans S, Ho CY, Houweling AC, Ingles J, Ingrey A, Jabbour A, James PA, Jansweijer JA, Jongbloed JDH, Keogh AM, Larrañaga-Moreira JM, Lekanne Deprez RH, Macciocca I, Macdonald PS, Mansencal N, Mansour J, Martinez-Veira C, McDonough B, McGaughran J, Medo K, Merlo M, Michalak E, Monserrat L, Mountain H, Muller SA, Murphy AM, Murray B, Oates EC, Ormondroyd E, Pachter N, Paldino A, Palmyre A, Pereira NL, Picard KC, Poplawski N, Prasad S, Proukhnitzky J, Pruny JF, Reant P, Richard P, Ronan A, Sedaghat-Hamedani F, Semsarian C, Storm G, Stroeks S, Syrris P, Taylor MRG, Thomson K, Thompson T, van Tintelen JP, Vissing CR, Waddell-Smith KE, Wallis M, Zentner D, Arnott C, Marian AJ, Oh J, Fokstuen S, James CA, Barriales-Villa R, Meder B, Wahbi K, Giudicessi JR, Parikh VN, Ware JS, Piriou N, Rooryck C, Lakdawala NK, Mestroni L, Sinagra G, Elliott PM, Watkins H, McNally EM, Charron P, van Spaendonck-Zwarts KY, Garcia-Pavia P, Peña-Peña ML, Mogensen J, Christensen AH, Bilinska ZT, Rasmussen TB, Seidman JG, Seidman CE, Te Riele ASJM, Verdonschot JAJ, Pinto YM, Christiaans I, Fatkin D.
Eur Heart J 2025-12-22
View full abstract on Pubmed

Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.

Authors: Authors: Bhattacharya R, Ward T, Kalejaiye TD, Mishra A, Leeman SM, Arzaghi H, Seidman JG, Seidman CE, Musah S.
Nat Biomed Eng 2025-11-03
View full abstract on Pubmed

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations.

Authors: Authors: Huang H, Wang Y, Zsengeller ZK, Gorham JM, Vemireddy V, Clark AJ, Pan H, Dreyfuss JM, Jotwani V, Shlipak MG, Sarnak MJ, Parikh CR, Thiessen-Philbrook H, Katz R, Waikar SS, Lake NJ, Lek M, Shi W, Puiu D, Hong YS, Seidman JG, Arking DE, Parikh SM.
Science 2025-10-09
View full abstract on Pubmed

Endocardial primary cilia and blood flow regulate EndoMT during endocardial cushion development.

Authors: Authors: Berg K, Gorham J, Lundt F, Seidman J, Brueckner M.
Nat Cardiovasc Res 2025-09-01
View full abstract on Pubmed

Enrichment of tandem repeat element variants near CHD genes identified by short- and long-read genome sequencing.

Authors: Authors: Suresh A, Morton SU, Quiat D, DePalma SR, Gorham JM, Brueckner M, Tristani-Firouzi M, Gelb BD, Seidman JG, Seidman CE.
BMC Med Genomics 2025-07-25
View full abstract on Pubmed

Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery.

Authors: Authors: Watkins WS, Hernandez EJ, Miller TA, Blue NR, Zimmerman RM, Griffiths ER, Frise E, Bernstein D, Boskovski MT, Brueckner M, Chung WK, Gaynor JW, Gelb BD, Goldmuntz E, Gruber PJ, Newburger JW, Roberts AE, Morton SU, Mayer JE, Seidman CE, Seidman JG, Shen Y, Wagner M, Yost HJ, Yandell M, Tristani-Firouzi M.
Nat Commun 2025-07-10
View full abstract on Pubmed

Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy.

Authors: Authors: Wang YJ, Singh K, Lokman AB, Deng S, Sunitha B, Coelho Lima J, Beglov J, Kelly M, Blease A, Fung JCK, Huang A, Attar M, Stork LA, Maguire ML, Schneider JE, Marston SB, Soilleux EJ, Dendrou CA, Coles M, Buckley CD, Seidman JG, Seidman CE, Redwood C, Ashrafian H, Watkins H.
Sci Transl Med 2025-07-09
View full abstract on Pubmed

GLP1R upregulation in mitral regurgitation observed at a single nucleus level.

Authors: Authors: Tiwari S, Beyer M, Aranki SF, Neyazi M, Oudit GY, Layton O, Seidman JG, Seidman CE, Muehlschlegel JD.
J Mol Cell Cardiol 2025-06-01
View full abstract on Pubmed

Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model.

Authors: Authors: Baka T, Moore J, Qin F, Yurista SR, Zhang A, He H, Chambers JM, Croteau D, Goel RK, Smith H, Wang MC, Chen CS, Hobai IA, Rombaldova M, Kuda O, Tardiff JC, Balschi JA, Pimentel DR, Seidman CE, Seidman JG, Emili A, Colucci WS, Luptak I.
Eur Heart J 2025-05-21
View full abstract on Pubmed