Jonathan G. Seidman

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School

617-432-7830

Publications

Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts.

Authors: Authors: Bick AG, Flannick J, Ito K, Cheng S, Vasan RS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, O'Donnell CJ, Wilson JG, Altshuler DM, Hirschhorn JN, Seidman JG, Seidman C.
Am J Hum Genet 2012-09-07
View full abstract on Pubmed

Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development.

Authors: Authors: Lage K, Greenway SC, Rosenfeld JA, Wakimoto H, Gorham JM, Segrè AV, Roberts AE, Smoot LB, Pu WT, Pereira AC, Mesquita SM, Tommerup N, Brunak S, Ballif BC, Shaffer LG, Donahoe PK, Daly MJ, Seidman JG, Seidman CE, Larsen LA.
Proc Natl Acad Sci U S A 2012-08-28
View full abstract on Pubmed

Spectrum of somatic mitochondrial mutations in five cancers.

Authors: Authors: Larman TC, DePalma SR, Hadjipanayis AG, Protopopov A, Zhang J, Gabriel SB, Chin L, Seidman CE, Kucherlapati R, Seidman JG.
Proc Natl Acad Sci U S A 2012-08-28
View full abstract on Pubmed

High-throughput multiplex sequencing of miRNA.

Authors: Authors: Vigneault F, Ter-Ovanesyan D, Alon S, Eminaga S, C Christodoulou D, Seidman JG, Eisenberg E, M Church G.
Curr Protoc Hum Genet 2012-04-01
View full abstract on Pubmed

Genetic testing for dilated cardiomyopathy in clinical practice.

Authors: Authors: Lakdawala NK, Funke BH, Baxter S, Cirino AL, Roberts AE, Judge DP, Johnson N, Mendelsohn NJ, Morel C, Care M, Chung WK, Jones C, Psychogios A, Duffy E, Rehm HL, White E, Seidman JG, Seidman CE, Ho CY.
J Card Fail 2012-04-01
View full abstract on Pubmed

Truncations of titin causing dilated cardiomyopathy.

Authors: Authors: Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE.
N Engl J Med 2012-02-16
View full abstract on Pubmed

Polycomb repressive complex 2 regulates normal development of the mouse heart.

Authors: Authors: He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT.
Circ Res 2012-02-03
View full abstract on Pubmed

CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.

Authors: Authors: Neckár J, Šilhavy J, Zídek V, Landa V, Mlejnek P, Šimáková M, Seidman JG, Seidman C, Kazdová L, Klevstig M, Novák F, Vecka M, Papoušek F, Houštek J, Drahota Z, Kurtz TW, Kolár F, Pravenec M.
Physiol Genomics 2012-02-01
View full abstract on Pubmed

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.

Authors: Authors: Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG.
Nat Genet 2012-01-22
View full abstract on Pubmed

Brazilian urban population genetic structure reveals a high degree of admixture.

Authors: Authors: Giolo SR, Soler JM, Greenway SC, Almeida MA, de Andrade M, Seidman JG, Seidman CE, Krieger JE, Pereira AC.
Eur J Hum Genet 2012-01-01
View full abstract on Pubmed