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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.
Authors: Authors: Schmitt JP, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, Maclennan DH, Seidman CE, Seidman JG, Lohse MJ.
Circulation
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E2F3 plays an essential role in cardiac development and function.
Authors: Authors: King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JA.
Cell Cycle
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Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish.
Authors: Authors: Wang L, Sewell WF, Kim SD, Shin JT, MacRae CA, Zon LI, Seidman JG, Seidman CE.
Development
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The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Authors: Authors: Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG.
PLoS One
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Shared genetic causes of cardiac hypertrophy in children and adults.
Authors: Authors: Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE.
N Engl J Med
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Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.
Authors: Authors: Tsoutsman T, Kelly M, Ng DC, Tan JE, Tu E, Lam L, Bogoyevitch MA, Seidman CE, Seidman JG, Semsarian C.
Circulation
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Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage.
Authors: Authors: Ofir M, Arad M, Porat E, Freimark D, Chepurko Y, Vidne BA, Seidman CE, Seidman JG, Kemp BE, Hochhauser E.
Biochem Pharmacol
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Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.
Authors: Authors: Palmer BM, Wang Y, Teekakirikul P, Hinson JT, Fatkin D, Strouse S, Vanburen P, Seidman CE, Seidman JG, Maughan DW.
Am J Physiol Heart Circ Physiol
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Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.
Authors: Authors: Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, Seidman JG, Seidman CE, Frey B, Perry M, Backx PH, Liu PP, MacLennan DH, Emili A.
Mol Cell Proteomics
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Eya4-deficient mice are a model for heritable otitis media.
Authors: Authors: Depreux FF, Darrow K, Conner DA, Eavey RD, Liberman MC, Seidman CE, Seidman JG.
J Clin Invest
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