Jonathan Seidman headshot

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Comparison of two murine models of familial hypertrophic cardiomyopathy.
Authors: Authors: McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JG.
Circ Res
View full abstract on Pubmed
Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis.
Authors: Authors: Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK.
Int Immunol
View full abstract on Pubmed
Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
Authors: Authors: Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG.
Mol Cell Biol
View full abstract on Pubmed
The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms.
Authors: Authors: Seidman JG, Seidman C.
Cell
View full abstract on Pubmed
Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy.
Authors: Authors: Kamisago M, Sharma SD, DePalma SR, Solomon S, Sharma P, McDonough B, Smoot L, Mullen MP, Woolf PK, Wigle ED, Seidman JG, Seidman CE.
N Engl J Med
View full abstract on Pubmed
An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy.
Authors: Authors: Fatkin D, McConnell BK, Mudd JO, Semsarian C, Moskowitz IG, Schoen FJ, Giewat M, Seidman CE, Seidman JG.
J Clin Invest
View full abstract on Pubmed
Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy.
Authors: Authors: Ho CY, Lever HM, DeSanctis R, Farver CF, Seidman JG, Seidman CE.
Circulation
View full abstract on Pubmed
Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease.
Authors: Authors: Kasahara H, Lee B, Schott JJ, Benson DW, Seidman JG, Seidman CE, Izumo S.
J Clin Invest
View full abstract on Pubmed
Dilated cardiomyopathy and sensorineural hearing loss: a heritable syndrome that maps to 6q23-24.
Authors: Authors: Schönberger J, Levy H, Grünig E, Sangwatanaroj S, Fatkin D, MacRae C, Stäcker H, Halpin C, Eavey R, Philbin EF, Katus H, Seidman JG, Seidman CE.
Circulation
View full abstract on Pubmed
Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy.
Authors: Authors: Tyska MJ, Hayes E, Giewat M, Seidman CE, Seidman JG, Warshaw DM.
Circ Res
View full abstract on Pubmed