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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Authors: Authors: Blanchard E, Seidman C, Seidman JG, LeWinter M, Maughan D.
Circ Res
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Familial dilated cardiomyopathy locus maps to chromosome 2q31.
Authors: Authors: Siu BL, Niimura H, Osborne JA, Fatkin D, MacRae C, Solomon S, Benson DW, Seidman JG, Seidman CE.
Circulation
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The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation.
Authors: Authors: Georgakopoulos D, Christe ME, Giewat M, Seidman CM, Seidman JG, Kass DA.
Nat Med
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Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy.
Authors: Authors: Gao WD, Pérez NG, Seidman CE, Seidman JG, Marbán E.
J Clin Invest
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Regulation of chamber-specific gene expression in the developing heart by Irx4.
Authors: Authors: Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL.
Science
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QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2.
Authors: Authors: Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK.
Nat Genet
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Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.
Authors: Authors: Fatkin D, Christe ME, Aristizabal O, McConnell BK, Srinivasan S, Schoen FJ, Seidman CE, Turnbull DH, Seidman JG.
J Clin Invest
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Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction.
Authors: Authors: Robertson NG, Lu L, Heller S, Merchant SN, Eavey RD, McKenna M, Nadol JB, Miyamoto RT, Linthicum FH, Lubianca Neto JF, Hudspeth AJ, Seidman CE, Morton CC, Seidman JG.
Nat Genet
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Haploinsufficiency of MSX1: a mechanism for selective tooth agenesis.
Authors: Authors: Hu G, Vastardis H, Bendall AJ, Wang Z, Logan M, Zhang H, Nelson C, Stein S, Greenfield N, Seidman CE, Seidman JG, Abate-Shen C.
Mol Cell Biol
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Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Authors: Authors: Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG.
Science
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