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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function.
Authors: Authors: Golitsina N, An Y, Greenfield NJ, Thierfelder L, Iizuka K, Seidman JG, Seidman CE, Lehrer SS, Hitchcock-DeGregori SE.
Biochemistry
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Cao-sensing receptor (CaR)-mediated activation of K+ channels is blunted in CaR gene-deficient mouse neurons.
Authors: Authors: Vassilev PM, Ho-Pao CL, Kanazirska MP, Ye C, Hong K, Seidman CE, Seidman JG, Brown EM.
Neuroreport
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Cytoskeletal changes in the brains of mice lacking calcineurin A alpha.
Authors: Authors: Kayyali US, Zhang W, Yee AG, Seidman JG, Potter H.
J Neurochem
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Various types of hereditary inclusion body myopathies map to chromosome 9p1-q1.
Authors: Authors: Argov Z, Tiram E, Eisenberg I, Sadeh M, Seidman CE, Seidman JG, Karpati G, Mitrani-Rosenbaum S.
Ann Neurol
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Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene.
Authors: Authors: Coviello DA, Maron BJ, Spirito P, Watkins H, Vosberg HP, Thierfelder L, Schoen FJ, Seidman JG, Seidman CE.
J Am Coll Cardiol
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Amyloid-beta proteins activate Ca(2+)-permeable channels through calcium-sensing receptors.
Authors: Authors: Ye C, Ho-Pao CL, Kanazirska M, Quinn S, Rogers K, Seidman CE, Seidman JG, Brown EM, Vassilev PM.
J Neurosci Res
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Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice.
Authors: Authors: Berul CI, Christe ME, Aronovitz MJ, Seidman CE, Seidman JG, Mendelsohn ME.
J Clin Invest
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Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome.
Authors: Authors: Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Seidman CE.
Nat Genet
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Genetic heterogeneity evidenced by low incidence of KAL-1 gene mutations in sporadic cases of gonadotropin-releasing hormone deficiency.
Authors: Authors: Georgopoulos NA, Pralong FP, Seidman CE, Seidman JG, Crowley WF, Vallejo M.
J Clin Endocrinol Metab
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Deficient cation channel regulation in neurons from mice with targeted disruption of the extracellular Ca2+-sensing receptor gene.
Authors: Authors: Ye C, Ho-Pao CL, Kanazirska M, Quinn S, Seidman CE, Seidman JG, Brown EM, Vassilev PM.
Brain Res Bull
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