Jonathan Seidman headshot

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Mutations in genes related to myocyte contraction and ventricular septum development in non-syndromic tetralogy of Fallot.
Authors: Authors: Harvey DC, Verma R, Sedaghat B, Hjelm BE, Morton SU, Seidman JG, Kumar SR.
Front Cardiovasc Med
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Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation.
Authors: Authors: Venturini G, Alvim JM, Padilha K, Toepfer CN, Gorham JM, Wasson LK, Biagi D, Schenkman S, Carvalho VM, Salgueiro JS, Cardozo KHM, Krieger JE, Pereira AC, Seidman JG, Seidman CE.
Front Cell Infect Microbiol
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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy.
Authors: Authors: Margara F, Psaras Y, Wang ZJ, Schmid M, Doste R, Garfinkel AC, Repetti GG, Seidman JG, Seidman CE, Rodriguez B, Toepfer CN, Bueno-Orovio A.
Sci Rep
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An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
Authors: Authors: Quiat D, Kim SW, Zhang Q, Morton SU, Pereira AC, DePalma SR, Willcox JAL, McDonough B, DeLaughter DM, Gorham JM, Curran JJ, Tumblin M, Nicolau Y, Artunduaga MA, Quintanilla-Dieck L, Osorno G, Serrano L, Hamdan U, Eavey RD, Seidman CE, Seidman JG.
Proc Natl Acad Sci U S A
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Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: a UK Biobank Analysis.
Authors: Authors: Hylind RJ, Pereira AC, Quiat D, Chandler SF, Roston TM, Pu WT, Bezzerides VJ, Seidman JG, Seidman CE, Abrams DJ.
Circ Genom Precis Med
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Neither cardiac mitochondrial DNA variation nor copy number contribute to congenital heart disease risk.
Authors: Authors: Willcox JAL, Geiger JT, Morton SU, McKean D, Quiat D, Gorham JM, Tai AC, DePalma S, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb B, Porter GA, Seidman JG, Seidman CE.
Am J Hum Genet
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Engineering a living cardiac pump on a chip using high-precision fabrication.
Authors: Authors: Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, Chen CS.
Sci Adv
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Genetics of cancer therapy-associated cardiotoxicity.
Authors: Authors: Kim Y, Seidman JG, Seidman CE.
J Mol Cell Cardiol
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Transcription factor protein interactomes reveal genetic determinants in heart disease.
Authors: Authors: Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D.
Cell
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A functional genomic approach to actionable gene fusions for precision oncology.
Authors: Authors: Li J, Lu H, Ng PK, Pantazi A, Ip CKM, Jeong KJ, Amador B, Tran R, Tsang YH, Yang L, Song X, Dogruluk T, Ren X, Hadjipanayis A, Bristow CA, Lee S, Kucherlapati M, Parfenov M, Tang J, Seth S, Mahadeshwar HS, Mojumdar K, Zeng D, Zhang J, Protopopov A, Seidman JG, Creighton CJ, Lu Y, Sahni N, Shaw KR, Meric-Bernstam F, Futreal A, Chin L, Scott KL, Kucherlapati R, Mills GB, Liang H.
Sci Adv
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