Konrad Hochedlinger

Konrad Hochedlinger, Ph.D.

Professor of Genetics, Massachusetts General Hospital
617-643-2075
Konrad Hochedlinger Website
Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage.
Authors: Authors: Bar-Nur O, Verheul C, Sommer AG, Brumbaugh J, Schwarz BA, Lipchina I, Huebner AJ, Mostoslavsky G, Hochedlinger K.
Nat Biotechnol
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The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
Authors: Authors: Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, Goren A, Rao A, Mostoslavsky R.
Nat Cell Biol
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Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency.
Authors: Authors: Li L, Walsh RM, Wagh V, James MF, Beauchamp RL, Chang YS, Gusella JF, Hochedlinger K, Ramesh V.
PLoS One
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Small molecules facilitate rapid and synchronous iPSC generation.
Authors: Authors: Bar-Nur O, Brumbaugh J, Verheul C, Apostolou E, Pruteanu-Malinici I, Walsh RM, Ramaswamy S, Hochedlinger K.
Nat Methods
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Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs.
Authors: Authors: Wu T, Liu Y, Wen D, Tseng Z, Tahmasian M, Zhong M, Rafii S, Stadtfeld M, Hochedlinger K, Xiao A.
Cell Stem Cell
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Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming.
Authors: Authors: West JA, Cook A, Alver BH, Stadtfeld M, Deaton AM, Hochedlinger K, Park PJ, Tolstorukov MY, Kingston RE.
Nat Commun
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Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
Authors: Authors: Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Voisin V, Clarke ID, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Malkin D, Northcott PA, Kool M, Pfister SM, Bader G, Hochedlinger K, Korshunov A, Taylor MD, Dirks PB.
Cancer Cell
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Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.
Authors: Authors: Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H.
J Exp Med
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Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea.
Authors: Authors: Bramhall NF, Shi F, Arnold K, Hochedlinger K, Edge AS.
Stem Cell Reports
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Nanog is dispensable for the generation of induced pluripotent stem cells.
Authors: Authors: Schwarz BA, Bar-Nur O, Silva JC, Hochedlinger K.
Curr Biol
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