Konrad Hochedlinger, Ph.D.
Professor of Genetics, Massachusetts General Hospital
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
Authors: Authors: Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Voisin V, Clarke ID, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Malkin D, Northcott PA, Kool M, Pfister SM, Bader G, Hochedlinger K, Korshunov A, Taylor MD, Dirks PB.
Cancer Cell
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Cancer Cell
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Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.
Authors: Authors: Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H.
J Exp Med
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J Exp Med
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Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea.
Authors: Authors: Bramhall NF, Shi F, Arnold K, Hochedlinger K, Edge AS.
Stem Cell Reports
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Stem Cell Reports
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Nanog is dispensable for the generation of induced pluripotent stem cells.
Authors: Authors: Schwarz BA, Bar-Nur O, Silva JC, Hochedlinger K.
Curr Biol
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Curr Biol
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Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.
Authors: Authors: Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH.
Mol Cell
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Mol Cell
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Rearranging the chromatin for pluripotency.
Authors: Authors: Ferrari F, Apostolou E, Park PJ, Hochedlinger K.
Cell Cycle
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Cell Cycle
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The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.
Authors: Authors: Wang L, Miao YL, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward JM, Burkholder A, Lipchina I, Fargo DC, Hochedlinger K, Shi Y, Williams CJ, Hu G.
Cell Stem Cell
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Cell Stem Cell
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Chromatin dynamics during cellular reprogramming.
Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation.
A variant CRISPR-Cas9 system adds versatility to genome engineering.