Louis Kunkel headshot

Louis Martens Kunkel, Ph.D.

Professor of Genetics and Pediatrics, Harvard Medical School
Director, Genomics Program
617-355-7576
Kunkel Lab Website
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.
Authors: Authors: Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ.
Nature
View full abstract on Pubmed
A new mouse model for evaluating the immunotherapy of human colorectal cancer.
Authors: Authors: Hörig H, Wainstein A, Long L, Kahn D, Soni S, Marcus A, Edelmann W, Kucherlapati R, Kaufman HL.
Cancer Res
View full abstract on Pubmed
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.
Authors: Authors: Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD.
Nat Genet
View full abstract on Pubmed
The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.
Authors: Authors: Kuraguchi M, Yang K, Wong E, Avdievich E, Fan K, Kolodner RD, Lipkin M, Brown AM, Kucherlapati R, Edelmann W.
Cancer Res
View full abstract on Pubmed
p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo.
Authors: Authors: Yang W, Velcich A, Mariadason J, Nicholas C, Corner G, Houston M, Edelmann W, Kucherlapati R, Holt PR, Augenlicht LH.
Cancer Res
View full abstract on Pubmed
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts.
Authors: Authors: Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng C, Kucherlapati R, Bottinger EP, Roberts AB.
J Biol Chem
View full abstract on Pubmed
Cancer. Telomerase meets its mismatch.
Authors: Authors: Kucherlapati R, DePinho RA.
Nature
View full abstract on Pubmed
Mouse models for human familial adenomatous polyposis.
Authors: Authors: Kucherlapati R, Lin DP, Edelmann W.
Semin Cancer Biol
View full abstract on Pubmed
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.
Authors: Authors: Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R.
Cell
View full abstract on Pubmed
A high-resolution map of human chromosome 12.
Authors: Authors: Montgomery KT, Lee E, Miller A, Lau S, Shim C, Decker J, Chiu D, Emerling S, Sekhon M, Kim R, Lenz J, Han J, Ioshikhes I, Renault B, Marondel I, Yoon SJ, Song K, Murty VV, Scherer S, Yonescu R, Kirsch IR, Ried T, McPherson J, Gibbs R, Kucherlapati R.
Nature
View full abstract on Pubmed