Luke Chao headshot

Luke H Chao, Ph.D.

Assistant Professor of Genetics, Harvard Medical School
617-724-2323
Chao Lab Website
SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy.
Authors: Authors: Ding C, Ndiaye PS, Campbell SR, Fry MY, Gong J, Wienbar SR, Gibbs W, Morquette P, Chao LH, Do MTH, Schwarz T.
J Clin Invest
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Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects.
Authors: Authors: Sabbah HN, Alder NN, Sparagna GC, Bruce JE, Stauffer BL, Chao LH, Pitceathly RDS, Maack C, Marcinek DJ.
Biomed Pharmacother
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The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture.
Authors: Authors: Navarro PP, Vettiger A, Hajdu R, Ananda VY, López-Tavares A, Schmid EW, Walter JC, Loose M, Chao LH, Bernhardt TG.
bioRxiv
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In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor.
Authors: Authors: Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Cardenas CLL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Lawton J, Kim N, Silverstein RA, Ferreira da Silva J, de la Cruz D, Richa R, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL.
bioRxiv
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Stress-mediated growth determines E. coli division site morphogenesis.
Authors: Authors: Pelech P, Navarro PP, Vettiger A, Chao LH, Allolio C.
bioRxiv
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Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2.
Authors: Authors: Boopathy S, Luce BE, Lugo CM, Hakim P, McDonald J, Kim HL, Ponce J, Ueberheide BM, Chao LH.
J Biol Chem
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Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation.
Authors: Authors: Bell TA, Luce BE, Hakim P, Ananda VY, Dardari H, Nguyen TH, Monshizadeh A, Chao LH.
Elife
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Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases.
Authors: Authors: Ferreira da Silva J, Tou CJ, King EM, Eller ML, Rufino-Ramos D, Ma L, Cromwell CR, Metovic J, Benning FMC, Chao LH, Eichler FS, Kleinstiver BP.
Nat Biotechnol
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Ancestral sequence reconstruction of Mic60 reveals a residue signature supporting respiration in yeast.
Authors: Authors: Benning FMC, Bell TA, Nguyen TH, Syau D, Connell LB, daCosta CJB, Chao LH.
bioRxiv
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In situ architecture of Opa1-dependent mitochondrial cristae remodeling.
Authors: Authors: Fry MY, Navarro PP, Hakim P, Ananda VY, Qin X, Landoni JC, Rath S, Inde Z, Lugo CM, Luce BE, Ge Y, McDonald JL, Ali I, Ha LL, Kleinstiver BP, Chan DC, Sarosiek KA, Chao LH.
EMBO J
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