Norbert Perrimon headshot

Norbert Perrimon, Ph.D.

James Stillman Professor of Developmental Biology, Harvard Medical School
Investigator, Howard Hughes Medical Institute
617-432-7672
Perrimon Lab Website
Genome-wide CRISPR knockout cell screening platform for the disease vector tick species Ixodes scapularis.
Authors: Authors: Butnaru M, McKenna W, Goswami S, Wu-Chuang A, Mameli E, Wilcox A, Quennesson L, Kim AR, Veal A, Chen W, Verzone H, Lane EA, Laukaitis-Yousey HJ, Araneo C, Singh N, Pedra JHF, Hu Y, Viswanatha R, Perrimon N, Mohr SE.
bioRxiv
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Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.
Authors: Authors: Xu Y, Stubbendieck RM, Viswanatha R, Krc A, Baik LS, Suh WS, Hu Y, Wang H, Yin L, Mameli E, van der Meij A, Carlson JR, Doxey AC, Stenmark P, Perrimon N, Currie CR, Dong M.
Nat Microbiol
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Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.
Authors: Authors: Marconcini M, Cruchet S, Goswami S, Viswanatha R, Butnaru M, De J, Roselli C, Hadjieconomou D, Perrimon N, Mohr SE, Benton R.
bioRxiv
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Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking.
Authors: Authors: Bosch JA, Beltran PMJ, Cavers C, LaGraff JT, Melanson R, Singh A, Chen W, Hu Y, Tattikota SG, Liu Y, Hashmi Y, Asara JM, Branon T, Ting AY, Carr SA, Perrimon N.
Nat Commun
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Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth.
Authors: Authors: Miao T, Liu Y, Qadiri M, Dasseux A, Asara JM, Hu Y, Sun X, Pliego-Alcántara LDC, Dibble CC, Perrimon N.
Nat Commun
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Lipids Regulate Export of Lysosomal Enzymes from the Endoplasmic Reticulum.
Authors: Authors: Xia B, Han M, Park I, Perrimon N.
bioRxiv
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DIOPT: the DRSC Integrative Ortholog Prediction Tool, 2026 update.
Authors: Authors: Hu Y, Comjean A, Gao C, Veal A, Yamamoto S, Mohr SE, Perrimon N.
bioRxiv
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Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila.
Authors: Authors: Han M, Xia B, Kim AR, Filine E, Stoneburner E, Miao T, Liu Y, Zirin J, Perrimon N.
Proc Natl Acad Sci U S A
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Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms.
Authors: Authors: Petsakou A, Filine E, Li M, Chen Y, Zheng A, Perrimon N.
Nat Commun
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Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis.
Authors: Authors: Lane EA, Petsakou A, Liu Y, Chen W, Qadiri M, Hu Y, Perrimon N.
PLoS Genet
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