Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

A phase I trial of adeno-associated virus serotype 1-?-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C.
Authors: Authors: Herson S, Hentati F, Rigolet A, Behin A, Romero NB, Leturcq F, Laforêt P, Maisonobe T, Amouri R, Haddad H, Audit M, Montus M, Masurier C, Gjata B, Georger C, Cheraï M, Carlier P, Hogrel JY, Herson A, Allenbach Y, Lemoine FM, Klatzmann D, Sweeney HL, Mulligan RC, Eymard B, Caizergues D, Voït T, Benveniste O.
Brain
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Neural correlates of inhibitory control in adult attention deficit/hyperactivity disorder: evidence from the Milwaukee longitudinal sample.
Authors: Authors: Mulligan RC, Knopik VS, Sweet LH, Fischer M, Seidenberg M, Rao SM.
Psychiatry Res
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Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy.
Authors: Authors: Schwenter F, Zarei S, Luy P, Padrun V, Bouche N, Lee JS, Mulligan RC, Morel P, Mach N.
Cancer Gene Ther
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Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation.
Authors: Authors: Sanchez CE, Tierney TS, Gale JT, Alavian KN, Sahin A, Lee JS, Mulligan RC, Carter BS.
J Neurosurg
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Telomere dysfunction induces metabolic and mitochondrial compromise.
Authors: Authors: Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA.
Nature
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Effects of nicotine withdrawal on verbal working memory and associated brain response.
Authors: Authors: Sweet LH, Mulligan RC, Finnerty CE, Jerskey BA, David SP, Cohen RA, Niaura RS.
Psychiatry Res
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The ARRIVE guidelines, a welcome improvement to standards for reporting animal research.
Authors: Authors: Danos O, Davies K, Lehn P, Mulligan R.
J Gene Med
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Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.
Authors: Authors: Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN.
J Clin Invest
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A fMRI Study of Verbal Working Memory, Cardiac Output, and Ejection Fraction in Elderly Patients with Cardiovascular Disease.
Authors: Authors: Irani F, Sweet LH, Haley AP, Gunstad JJ, Jerskey BA, Mulligan RC, Jefferson AL, Poppas A, Cohen RA.
Brain Imaging Behav
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Genetically engineered T cells to target EGFRvIII expressing glioblastoma.
Authors: Authors: Bullain SS, Sahin A, Szentirmai O, Sanchez C, Lin N, Baratta E, Waterman P, Weissleder R, Mulligan RC, Carter BS.
J Neurooncol
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