Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Relative contributions of the cerebellar vermis and prefrontal lobe volumes on cognitive function across the adult lifespan.
Authors: Authors: Paul R, Grieve SM, Chaudary B, Gordon N, Lawrence J, Cooper N, Clark CR, Kukla M, Mulligan R, Gordon E.
Neurobiol Aging
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A mammalian cell-based assay for screening inhibitors of RNA cleavage.
Authors: Authors: Yen L, Stockwell BR, Mulligan RC.
Methods Mol Biol
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Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis.
Authors: Authors: Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ.
Proc Natl Acad Sci U S A
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Lack of toxicity of alpha-sarcoglycan overexpression supports clinical gene transfer trial in LGMD2D.
Authors: Authors: Rodino-Klapac LR, Lee JS, Mulligan RC, Clark KR, Mendell JR.
Neurology
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Successful inhibition of intracranial human glioblastoma multiforme xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: laboratory investigation.
Authors: Authors: Szentirmai O, Baker CH, Bullain SS, Lin N, Takahashi M, Folkman J, Mulligan RC, Carter BS.
J Neurosurg
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Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome.
Authors: Authors: Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A.
J Clin Invest
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Imaging phonological similarity effects on verbal working memory.
Authors: Authors: Sweet LH, Paskavitz JF, Haley AP, Gunstad JJ, Mulligan RC, Nyalakanti PK, Cohen RA.
Neuropsychologia
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Side population hematopoietic stem cells promote wound healing in diabetic mice.
Authors: Authors: Chan RK, Garfein E, Gigante PR, Liu P, Agha RA, Mulligan R, Orgill DP.
Plast Reconstr Surg
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Engineering high-speed allosteric hammerhead ribozymes.
Authors: Authors: Link KH, Guo L, Ames TD, Yen L, Mulligan RC, Breaker RR.
Biol Chem
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Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.
Authors: Authors: Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE.
Leukemia
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