Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Induction of protective anti-tumor immunity by gene-modified dendritic cells.
Authors: Authors: McArthur JG, Mulligan RC.
J Immunother
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In vivo and in vitro modulation of immune stimulatory capacity of primary dendritic cells by adenovirus-mediated gene transduction.
Authors: Authors: Sonderbye L, Feng S, Yacoubian S, Buehler H, Ahsan N, Mulligan R, Langhoff E.
Exp Clin Immunogenet
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Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species.
Authors: Authors: Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP.
Nat Med
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Long-term in vivo expression of the MFG-ADA retroviral vector in rhesus monkeys transplanted with transduced bone marrow cells.
Authors: Authors: Kaptein LC, Van Beusechem VW, Rivière I, Mulligan RC, Valerio D.
Hum Gene Ther
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Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo.
Authors: Authors: Lindemann D, Patriquin E, Feng S, Mulligan RC.
Mol Med
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Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer.
Authors: Authors: Simons JW, Jaffee EM, Weber CE, Levitsky HI, Nelson WG, Carducci MA, Lazenby AJ, Cohen LK, Finn CC, Clift SM, Hauda KM, Beck LA, Leiferman KM, Owens AH, Piantadosi S, Dranoff G, Mulligan RC, Pardoll DM, Marshall FF.
Cancer Res
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A case report: immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy.
Authors: Authors: Ellem KA, O'Rourke MG, Johnson GR, Parry G, Misko IS, Schmidt CW, Parsons PG, Burrows SR, Cross S, Fell A, Li CL, Bell JR, Dubois PJ, Moss DJ, Good MF, Kelso A, Cohen LK, Dranoff G, Mulligan RC.
Cancer Immunol Immunother
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Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo.
Authors: Authors: Lieschke GJ, Rao PK, Gately MK, Mulligan RC.
Nat Biotechnol
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A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor.
Authors: Authors: Dranoff G, Soiffer R, Lynch T, Mihm M, Jung K, Kolesar K, Liebster L, Lam P, Duda R, Mentzer S, Singer S, Tanabe K, Johnson R, Sober A, Bhan A, Clift S, Cohen L, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Mulligan RC.
Hum Gene Ther
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A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.
Authors: Authors: Ory DS, Neugeboren BA, Mulligan RC.
Proc Natl Acad Sci U S A
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