Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

A gene transfer system establishes interleukin-6 neither promotes nor suppresses renal injury.
Authors: Authors: Naito T, Yokoyama H, Moore KJ, Dranoff G, Mulligan RC, Kelley VR.
Am J Physiol
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Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1.
Authors: Authors: Büeler H, Mulligan RC.
Mol Med
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Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways.
Authors: Authors: Huang YY, Bach ME, Lipp HP, Zhuo M, Wolfer DP, Hawkins RD, Schoonjans L, Kandel ER, Godfraind JM, Mulligan R, Collen D, Carmeliet P.
Proc Natl Acad Sci U S A
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PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.
Authors: Authors: Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LH, Ho C, Mulligan RC, Abou-Samra AB, Jüppner H, Segre GV, Kronenberg HM.
Science
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Macrophage growth factors introduced into the kidney initiate renal injury.
Authors: Authors: Naito T, Yokoyama H, Moore KJ, Dranoff G, Mulligan RC, Kelley VR.
Mol Med
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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.
Authors: Authors: Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D.
Science
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Adoptive immunotherapy of cancer with activated lymph node cells primed in vivo with autologous tumor cells transduced with the GM-CSF gene.
Authors: Authors: Chang AE, Sondak VK, Bishop DK, Nickoloff BJ, Mulligan RC, Mulé JJ.
Hum Gene Ther
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Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation.
Authors: Authors: Ikegami M, Ueda T, Hull W, Whitsett JA, Mulligan RC, Dranoff G, Jobe AH.
Am J Physiol
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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
Authors: Authors: Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC.
J Exp Med
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Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice.
Authors: Authors: Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA.
J Clin Invest
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