Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Generation and characterization of urokinase receptor-deficient mice.
Authors: Authors: Dewerchin M, Nuffelen AV, Wallays G, Bouché A, Moons L, Carmeliet P, Mulligan RC, Collen D.
J Clin Invest
View full abstract on Pubmed
Evolving concepts in the diagnosis and treatment of arterial high flow priapism.
Authors: Authors: Hakim LS, Kulaksizoglu H, Mulligan R, Greenfield A, Goldstein I.
J Urol
View full abstract on Pubmed
Gene transfer of macrophage growth factors into the kidney of lpr mice initiates renal injury.
Authors: Authors: Yokoyama H, Naito T, Dranoff G, Mulligan RC, Rubin-Kelley V.
Contrib Nephrol
View full abstract on Pubmed
Increased levels of spliced RNA account for augmented expression from the MFG retroviral vector in hematopoietic cells.
Authors: Authors: Krall WJ, Skelton DC, Yu XJ, Riviere I, Lehn P, Mulligan RC, Kohn DB.
Gene Ther
View full abstract on Pubmed
Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators.
Authors: Authors: Leonardsson G, Peng XR, Liu K, Nordström L, Carmeliet P, Mulligan R, Collen D, Ny T.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Transduction of LacZ gene into leukemia cells using viral vectors of retrovirus and adenovirus.
Authors: Authors: Tani K, Lin T, Hibino H, Takahashi K, Nakazaki Y, Takahashi S, Nagayama H, Ozawa K, Saitoh I, Mulligan R, et al.
Leukemia
View full abstract on Pubmed
Gene therapy of metastatic cancer by in vivo retroviral gene targeting.
Authors: Authors: Hurford RK, Dranoff G, Mulligan RC, Tepper RI.
Nat Genet
View full abstract on Pubmed
Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.
Authors: Authors: Rivière I, Brose K, Mulligan RC.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.
Authors: Authors: Sadelain M, Wang CH, Antoniou M, Grosveld F, Mulligan RC.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.
Authors: Authors: Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan RC, Collen D.
Ann N Y Acad Sci
View full abstract on Pubmed