Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Purification and characterization of retrovirally transduced hematopoietic stem cells.
Authors: Authors: Spain LM, Mulligan RC.
Proc Natl Acad Sci U S A
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High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range. 1984.
Authors: Authors: Cone RD, Mulligan RC.
Biotechnology
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Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.
Authors: Authors: Berger HA, Anderson MP, Gregory RJ, Thompson S, Howard PW, Maurer RA, Mulligan R, Smith AE, Welsh MJ.
J Clin Invest
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Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.
Authors: Authors: Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, Welsh MJ.
Science
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Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.
Authors: Authors: Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC.
Cell
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Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes.
Authors: Authors: Wilson JM, Chowdhury NR, Grossman M, Wajsman R, Epstein A, Mulligan RC, Chowdhury JR.
Proc Natl Acad Sci U S A
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Negative regulation of human c-fos expression by the retinoblastoma gene product.
Authors: Authors: Robbins PD, Horowitz JM, Mulligan RC.
Nature
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Evidence that the level of the p55 component of the interleukin (IL) 2 receptor can control IL 2 responsiveness in a murine IL 3-dependent cell.
Authors: Authors: Collins MK, Malde P, Miyajima A, Arai K, Smith KA, Mulligan RC.
Eur J Immunol
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Expression of human adenosine deaminase in mice reconstituted with retrovirus-transduced hematopoietic stem cells.
Authors: Authors: Wilson JM, Danos O, Grossman M, Raulet DH, Mulligan RC.
Proc Natl Acad Sci U S A
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Antisense RNA complementary to 3' coding and noncoding sequences of creatine kinase is a potent inhibitor of translation in vivo.
Authors: Authors: Ch'ng JL, Mulligan RC, Schimmel P, Holmes EW.
Proc Natl Acad Sci U S A
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