Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Transfer of a mutant dihydrofolate reductase gene into pre- and postimplantation mouse embryos by a replication-competent retrovirus vector.
Authors: Authors: Stuhlmann H, Jaenisch R, Mulligan RC.
J Virol
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Implantation of vascular grafts lined with genetically modified endothelial cells.
Authors: Authors: Wilson JM, Birinyi LK, Salomon RN, Libby P, Callow AD, Mulligan RC.
Science
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Restoration of growth potential in paraclones of human keratinocytes by a viral oncogene.
Authors: Authors: Barrandon Y, Morgan JR, Mulligan RC, Green H.
Proc Natl Acad Sci U S A
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Repression of the IgH enhancer in teratocarcinoma cells associated with a novel octamer factor.
Authors: Authors: Lenardo MJ, Staudt L, Robbins P, Kuang A, Mulligan RC, Baltimore D.
Science
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Construction and properties of replication-competent murine retroviral vectors encoding methotrexate resistance.
Authors: Authors: Stuhlmann H, Jaenisch R, Mulligan RC.
Mol Cell Biol
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Genetically modified endothelial cells in the treatment of human diseases.
Authors: Authors: Wilson JM, Birinyi LK, Salomon RN, Libby P, Callow AD, Mulligan RC.
Trans Assoc Am Physicians
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Use of retroviral vectors for mapping of splice sites in cottontail rabbit papillomavirus.
Authors: Authors: Dostatni N, Yaniv M, Danos O, Mulligan RC.
J Gen Virol
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Transfer of functional EGF receptors to an IL3-dependent cell line.
Authors: Authors: Collins MK, Downward J, Miyajima A, Maruyama K, Arai K, Mulligan RC.
J Cell Physiol
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Two dominant-acting selectable markers for gene transfer studies in mammalian cells.
Authors: Authors: Hartman SC, Mulligan RC.
Proc Natl Acad Sci U S A
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Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo.
Authors: Authors: Guild BC, Finer MH, Housman DE, Mulligan RC.
J Virol
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