Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Rescue of type I collagen-deficient phenotype by retroviral-vector-mediated transfer of human pro alpha 1(I) collagen gene into Mov-13 cells.
Authors: Authors: Stacey A, Mulligan R, Jaenisch R.
J Virol
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Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow.
Authors: Authors: Williams DA, Hsieh K, DeSilva A, Mulligan RC.
J Exp Med
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Tissue-specific expression of functionally rearranged lambda 1 Ig gene through a retrovirus vector.
Authors: Authors: Cone RD, Reilly EB, Eisen HN, Mulligan RC.
Science
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Expression of human class II major histocompatibility complex antigens using retrovirus vectors.
Authors: Authors: Korman AJ, Frantz JD, Strominger JL, Mulligan RC.
Proc Natl Acad Sci U S A
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Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector.
Authors: Authors: Cone RD, Weber-Benarous A, Baorto D, Mulligan RC.
Mol Cell Biol
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Efficient and stable expression of recombinant fibronectin polypeptides.
Authors: Authors: Schwarzbauer JE, Mulligan RC, Hynes RO.
Proc Natl Acad Sci U S A
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Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.
Authors: Authors: Auffray C, Lillie JW, Korman AJ, Boss JM, Fréchin N, Guillemot F, Cooper J, Mulligan RC, Strominger JL.
Immunogenetics
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Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses.
Authors: Authors: Soriano P, Cone RD, Mulligan RC, Jaenisch R.
Science
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Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells.
Authors: Authors: Barklis E, Mulligan RC, Jaenisch R.
Cell
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Developmental potential and dynamic behavior of hematopoietic stem cells.
Authors: Authors: Lemischka IR, Raulet DH, Mulligan RC.
Cell
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