Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice.
Authors: Authors: Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB.
Blood
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Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma.
Authors: Authors: Salgia R, Lynch T, Skarin A, Lucca J, Lynch C, Jung K, Hodi FS, Jaklitsch M, Mentzer S, Swanson S, Lukanich J, Bueno R, Wain J, Mathisen D, Wright C, Fidias P, Donahue D, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Sugarbaker D, Mihm M, Dranoff G.
J Clin Oncol
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Adenovirus-mediated delivery of a soluble form of the VEGF receptor Flk1 delays the growth of murine and human pancreatic adenocarcinoma in mice.
Authors: Authors: Tseng JF, Farnebo FA, Kisker O, Becker CM, Kuo CJ, Folkman J, Mulligan RC.
Surgery
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Genetic interventions for vein bypass graft disease: a review.
Authors: Authors: Conte MS, Mann MJ, Simosa HF, Rhynhart KK, Mulligan RC.
J Vasc Surg
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"Stemness": transcriptional profiling of embryonic and adult stem cells.
Authors: Authors: Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA.
Science
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Advanced renal cell carcinoma treated with granulocyte-macrophage colony-stimulating factor gene therapy: a clinical course of the first Japanese experience.
Authors: Authors: Kawai K, Tani K, Yamashita N, Tomikawa S, Eriguchi M, Fujime M, Okumura K, Kakizoe T, Clift S, Ando D, Mulligan R, Yamauchi A, Noguchi M, Asano S, Akaza H.
Int J Urol
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Use of CD9 expression to enrich for porcine hematopoietic progenitors.
Authors: Authors: Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MA.
Exp Hematol
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Gene therapy for pancreatic cancer.
Authors: Authors: Tseng JF, Mulligan RC.
Surg Oncol Clin N Am
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Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors.
Authors: Authors: Niederman TM, Ghogawala Z, Carter BS, Tompkins HS, Russell MM, Mulligan RC.
Proc Natl Acad Sci U S A
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Gene therapy of prostate cancer with the soluble vascular endothelial growth factor receptor Flk1.
Authors: Authors: Becker CM, Farnebo FA, Iordanescu I, Behonick DJ, Shih MC, Dunning P, Christofferson R, Mulligan RC, Taylor GA, Kuo CJ, Zetter BR.
Cancer Biol Ther
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