Stephen Elledge headshot
Stephen J. Elledge
Gregor Mendel Professor of Genetics and of Medicine
MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.
Authors: Authors: Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K.
Cancer Discov
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Tissue-specificity in cancer: The rule, not the exception.
Authors: Authors: Haigis KM, Cichowski K, Elledge SJ.
Science
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
Authors: Authors: Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ.
Mol Cell
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Sequencer Hacking Unlocks Quantitative Protein Studies.
Authors: Authors: Barber KW, Elledge SJ.
Mol Cell
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A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach.
Authors: Authors: Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY.
J Neurosci
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Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.
Authors: Authors: Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JL.
J Exp Med
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Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.
Authors: Authors: Liao S, Maertens O, Cichowski K, Elledge SJ.
Genes Dev
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The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.
Authors: Authors: Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ.
Cell
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C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.
Authors: Authors: Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS.
Mol Cell
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Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.
Authors: Authors: Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ.
Cell
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