Stephen J. Elledge

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital

Professor of Medicine, Brigham and Women's Hospital

617-525-4510

Elledge Lab Website

Additional Websites
Publications

HHMI Investigator

T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics.

Authors: Authors: Abdelfattah NS, Kula T, Elledge SJ.
Immunity 2024-11-26
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Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.

Authors: Authors: Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA.
Nat Commun 2024-11-15
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Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.

Authors: Authors: Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA.
Nat Commun 2024-10-12
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Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability.

Authors:
J Cell Biol 2024-08-05
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of a-synuclein inclusions.

Authors: Authors: Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V.
Neuron 2024-07-23
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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer.

Authors: Authors: Hillis AL, Martin TD, Manchester HE, Högström J, Zhang N, Lecky E, Kozlova N, Lee J, Persky NS, Root DE, Brown M, Cichowski K, Elledge SJ, Muranen T, Fruman DA, Barry ST, Clohessy JG, Madsen RR, Toker A.
Cancer Res 2024-07-18
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High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits.

Authors:
Nat Biotechnol 2024-07-02
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Proteasomal control of anti-CRISPRs for the regulation of CRISPR/Cas9 activity using Cas9-ACROBAT.

Authors: Authors: Martin TD, Watson EV, Choi MY, Nabet B, Gray NS, Xu Q, Elledge SJ.
bioRxiv 2024-05-13
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Mechanism of ?-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase.

Authors: Authors: Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C.
Nat Commun 2024-04-26
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Serologic Response to the Epstein-Barr Virus Peptidome and the Risk for Multiple Sclerosis.

Authors: Authors: Cortese M, Leng Y, Bjornevik K, Mitchell M, Healy BC, Mina MJ, Mancuso JD, Niebuhr DW, Munger KL, Elledge SJ, Ascherio A.
JAMA Neurol 2024-03-18
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