Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.
Authors: Authors: Grant DW, Tan S, Ramage DE, Li MZ, Di Y, Tchasovnikarova IA, Weekes MP, Elledge SJ, Warren AJ, Timms RT.
bioRxiv
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An RNA splicing system that excises DNA transposons from animal mRNAs.
Authors: Authors: Zhao LW, Nardone C, Chang C, Paulo JA, Elledge SJ, Kennedy S.
Nature
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Degrons: defining the rules of protein degradation.
Authors: Authors: Zhang Z, Mena EL, Timms RT, Koren I, Elledge SJ.
Nat Rev Mol Cell Biol
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Authors: Authors: Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi NC, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X.
Mol Cell
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Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation.
Authors: Authors: Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.
Genes Dev
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Epstein-Barr Virus Exposure Precedes Crohn`s Disease Development.
Authors: Authors: Nandy A, Petralia F, Porter C, Elledge S, Colombel JF, Snapper SB.
Gastroenterology
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Authors: Authors: Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi N, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X.
bioRxiv
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of a-synuclein inclusions.
Authors: Authors: Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V.
Neuron
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An RNA Splicing System that Excises Transposons from Animal mRNAs.
Authors: Authors: Zhao LW, Nardone C, Paulo JA, Elledge SJ, Kennedy S.
bioRxiv
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Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
Authors: Authors: Joung J, Heo Y, Kim Y, Kim J, Choi H, Jeon T, Jang Y, Kim EJ, Lee SH, Suh JM, Elledge SJ, Kim MS, Kang C.
Nat Commun
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