Stephen J. Elledge, Ph.D.
Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
The T cell receptor sequence influences the likelihood of T cell memory formation.
Authors: Authors: Lagattuta KA, Kohlgruber AC, Abdelfattah NS, Nathan A, Rumker L, Birnbaum ME, Elledge SJ, Raychaudhuri S.
Cell Rep
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Cell Rep
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T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics.
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.
Authors: Authors: Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA.
Nat Commun
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Nat Commun
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Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Authors: Authors: Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA.
Nat Commun
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Nat Commun
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Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability.
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of a-synuclein inclusions.
Authors: Authors: Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V.
Neuron
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Neuron
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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer.
Authors: Authors: Hillis AL, Martin TD, Manchester HE, Högström J, Zhang N, Lecky E, Kozlova N, Lee J, Persky NS, Root DE, Brown M, Cichowski K, Elledge SJ, Muranen T, Fruman DA, Barry ST, Clohessy JG, Madsen RR, Toker A.
Cancer Res
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Cancer Res
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High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits.
Proteasomal control of anti-CRISPRs for the regulation of CRISPR/Cas9 activity using Cas9-ACROBAT.
Authors: Authors: Martin TD, Watson EV, Choi MY, Nabet B, Gray NS, Xu Q, Elledge SJ.
bioRxiv
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bioRxiv
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Mechanism of ?-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase.
Authors: Authors: Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C.
Nat Commun
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Nat Commun
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