Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.
Authors: Authors: Grant DW, Tan S, Ramage DE, Li MZ, Di Y, Tchasovnikarova IA, Weekes MP, Elledge SJ, Warren AJ, Timms RT.
Mol Cell
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Reflections on the early days of the DNA damage response pathway in eukaryotes.
Authors: Authors: Elledge SJ.
Genetics
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Proteasomal surveillance of exposed cysteines.
Authors: Authors: Mena EL, Dong KC, Kairouz A, Donovan KA, Soliman MA, Huang HT, Yildiran B, Fischer ES, Sherwood RI, Timms RT, Martin A, Elledge SJ.
bioRxiv
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Humoral pregnancy analyses reveal strategies for fetal protection and aberrancy in miscarriage.
Authors: Authors: Sie BM, Leng Y, Nziza N, Mitchell MM, Webb NE, Lee Y, Mumford SL, Schisterman EF, Larman HB, Julg B, Alter G, Elledge SJ.
Cell Rep Med
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Changes in the transcriptome and synthetic lethal dependencies following KRAS mutant expression reveal profound tissue specificity.
Authors: Authors: Martin TD, Choi MY, McBride JC, Elledge SJ.
Proc Natl Acad Sci U S A
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Retraction Note: Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.
Authors: Authors: Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MIH, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT.
Sci Rep
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The diverse functions of viral microproteins.
Authors: Authors: Chen-Neumann YH, Grauvogel L, Zhang AS, Michaelis AC, Heymann T, Zollbrecht E, Engel P, Pensl C, Yost KE, Suen W, Sinha S, Neumann EN, Elledge SJ, Hopfner KP, Gewurz BE, Mann M, Weissman JS.
bioRxiv
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Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion.
Authors: Authors: Glassman CR, Baek K, Hou G, Zeng Q, Nardone C, Juergens KB, Fujimura E, O'Leary CN, Li MZ, Paulo JA, Fischer ES, Ding S, Harper JW, Elledge SJ.
Science
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A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.
Authors: Authors: Fujimura E, O'Leary CN, Li MZ, Roberts RA, Glassman CR, Paulo JA, Jiang H, Abdelfattah NS, Wooten EC, Mirman Z, Harper JW, Cole PA, Elledge SJ.
Cell
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Persistence of memory: lifespan dynamics of the human antiviral antibody reactome.
Authors: Authors: Mitchell MM, Kula T, Remmel JL, Xia S, Shrock EL, Leng Y, Larman HB, Chen Y, Knip M, Cortese M, Mina MJ, Ascherio A, Elledge SJ.
Nat Commun
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