Stephen Elledge headshot
Stephen J. Elledge, Ph.D
Gregor Mendel Professor of Genetics and of Medicine
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
Authors: Authors: Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJ.
Mol Cell
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High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.
Authors: Authors: Bruno PM, Timms RT, Abdelfattah NS, Leng Y, Lelis FJN, Wesemann DR, Yu XG, Elledge SJ.
Nat Biotechnol
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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Authors: Authors: Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I.
Cell
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Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1.
Authors: Authors: Oreskovic E, Wheeler EC, Mengwasser KE, Fujimura E, Martin TD, Tothova Z, Elledge SJ.
Proc Natl Acad Sci U S A
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Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.
Authors: Authors: Patten JJ, Keiser PT, Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, do Valle I, Geoghegan-Barek K, Anantpadma M, Boytz R, Berrigan JL, Hulsey-Stubbs S, Ayazika T, O'Leary C, Jalloh S, Wagner F, Ayehunie S, Elledge SJ, Anderson D, Loscalzo J, Zitnik M, Gummuluru S, Namchuk MN, Barabási AL, Davey RA.
bioRxiv
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V-CARMA: A tool for the detection and modification of antigen-specific T cells.
Authors: Authors: Guo XJ, Elledge SJ.
Proc Natl Acad Sci U S A
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Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.
Authors: Authors: Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL, Ascherio A.
Science
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A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.
Authors: Authors: Patel RS, Romero R, Watson EV, Liang AC, Burger M, Westcott PMK, Mercer KL, Bronson RT, Wooten EC, Bhutkar A, Jacks T, Elledge SJ.
Nat Commun
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Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Authors: Authors: Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X.
Nat Commun
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Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids.
Authors: Authors: Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala D, Ferrer E, Conahan C, Perea Del Pino S, Grossman J, Elledge SJ, Hidalgo M, Muthuswamy SK.
J Immunother Cancer
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