Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines.
Authors: Authors: Jena KK, Qu P, Baracco L, Saghaei S, Allahyari Z, Boehmer D, Mitchell M, Dillen CA, Li HY, Liu E, Poli V, Dufies O, Hoytema van Konijnenburg DP, Spreafico R, Bi C, Hall R, Kruppa MD, Ma Z, Gravitte A, Lowman DW, Ensley HE, Marty P, Boyer L, Collomp R, Williams DL, Ma VP, Lee PY, Nigrovic PA, Karp JM, Elledge SJ, Wesemann DR, Wu Y, Frieman M, Zanoni I.
Nat Immunol
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Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis.
Authors: Authors: Neyazi M, Venturini G, Brown KJ, Choi Y, Gorham JM, Layton OG, Verma A, Wang AJ, Gross RT, McDonough BA, Mendiola Pla M, Viveiros A, DeLaughter DM, DePalma SR, Kim Y, Reichart D, Wakimoto H, Elledge SJ, Divakaran S, Mitchell RN, Koh J, Park JB, Bowles DE, Glass C, Oudit GY, Seidman JG, Seidman CE.
Circulation
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Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.
Authors: Authors: Grant DW, Tan S, Ramage DE, Li MZ, Di Y, Tchasovnikarova IA, Weekes MP, Elledge SJ, Warren AJ, Timms RT.
bioRxiv
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An RNA splicing system that excises DNA transposons from animal mRNAs.
Authors: Authors: Zhao LW, Nardone C, Chang C, Paulo JA, Elledge SJ, Kennedy S.
Nature
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Structure of the TXNL1-bound proteasome.
Authors: Authors: Gao J, Nardone C, Yip MCJ, Chino H, Gu X, Mirman Z, Rale MJ, Paulo JA, Elledge SJ, Shao S.
Nat Struct Mol Biol
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Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost.
Authors: Authors: Chen G, Nguyen T, McKay LGA, Nakka SS, Hu P, McBride J, Liang AC, Olson R, Moon JJ, Luster AD, Griffiths A, Elledge SJ.
Sci Adv
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Degrons: defining the rules of protein degradation.
Authors: Authors: Zhang Z, Mena EL, Timms RT, Koren I, Elledge SJ.
Nat Rev Mol Cell Biol
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Authors: Authors: Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi NC, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X.
Mol Cell
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Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation.
Authors: Authors: Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.
Genes Dev
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Epstein-Barr Virus Exposure Precedes Crohn`s Disease Development.
Authors: Authors: Nandy A, Petralia F, Porter C, Elledge S, Colombel JF, Snapper SB.
Gastroenterology
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