Stephen Elledge headshot
Stephen J. Elledge, Ph.D
Gregor Mendel Professor of Genetics and of Medicine
617-525-4510
Elledge Lab Website
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Authors: Authors: Scott DC, King MT, Baek K, Gee CT, Kalathur R, Li J, Purser N, Nourse A, Chai SC, Vaithiyalingam S, Chen T, Lee RE, Elledge SJ, Kleiger G, Schulman BA.
Mol Cell
View full abstract on Pubmed
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
Authors: Authors: Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJ.
Mol Cell
View full abstract on Pubmed
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.
Authors: Authors: Bruno PM, Timms RT, Abdelfattah NS, Leng Y, Lelis FJN, Wesemann DR, Yu XG, Elledge SJ.
Nat Biotechnol
View full abstract on Pubmed
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Authors: Authors: Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I.
Cell
View full abstract on Pubmed
Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1.
Authors: Authors: Oreskovic E, Wheeler EC, Mengwasser KE, Fujimura E, Martin TD, Tothova Z, Elledge SJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.
Authors: Authors: Patten JJ, Keiser PT, Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, do Valle I, Geoghegan-Barek K, Anantpadma M, Boytz R, Berrigan JL, Hulsey-Stubbs S, Ayazika T, O'Leary C, Jalloh S, Wagner F, Ayehunie S, Elledge SJ, Anderson D, Loscalzo J, Zitnik M, Gummuluru S, Namchuk MN, Barabási AL, Davey RA.
bioRxiv
View full abstract on Pubmed
V-CARMA: A tool for the detection and modification of antigen-specific T cells.
Authors: Authors: Guo XJ, Elledge SJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.
Authors: Authors: Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL, Ascherio A.
Science
View full abstract on Pubmed
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.
Authors: Authors: Patel RS, Romero R, Watson EV, Liang AC, Burger M, Westcott PMK, Mercer KL, Bronson RT, Wooten EC, Bhutkar A, Jacks T, Elledge SJ.
Nat Commun
View full abstract on Pubmed
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Authors: Authors: Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X.
Nat Commun
View full abstract on Pubmed