Stephen Elledge headshot
Stephen J. Elledge, Ph.D
Gregor Mendel Professor of Genetics and of Medicine
617-525-4510
Elledge Lab Website
Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.
Authors: Authors: Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJ.
Mol Cell
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Defining E3 ligase-substrate relationships through multiplex CRISPR screening.
Authors: Authors: Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJ.
Nat Cell Biol
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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.
Authors: Authors: Gu X, Nardone C, Kamitaki N, Mao A, Elledge SJ, Greenberg ME.
Science
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Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn.
Authors: Authors: Liebhoff AM, Venkataraman T, Morgenlander WR, Na M, Kula T, Waugh K, Morrison C, Rewers M, Longman R, Round J, Elledge S, Ruczinski I, Langmead B, Larman HB.
bioRxiv
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Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology.
Authors: Authors: Mitchell MM, Leng Y, Boppana S, Britt WJ, Gutierrez Sanchez LH, Elledge SJ.
Sci Transl Med
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ERa-associated translocations underlie oncogene amplifications in breast cancer.
Authors: Authors: Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ.
Nature
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Ubiquitin-independent proteasomal degradation driven by C-degron pathways.
Authors: Authors: Makaros Y, Raiff A, Timms RT, Wagh AR, Gueta MI, Bekturova A, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I.
Mol Cell
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Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.
Authors: Authors: Shrock EL, Timms RT, Kula T, Mena EL, West AP, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJ.
Science
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E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Authors: Authors: Scott DC, King MT, Baek K, Gee CT, Kalathur R, Li J, Purser N, Nourse A, Chai SC, Vaithiyalingam S, Chen T, Lee RE, Elledge SJ, Kleiger G, Schulman BA.
Mol Cell
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A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
Authors: Authors: Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJ.
Mol Cell
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