Stephen Elledge headshot

Stephen J. Elledge, Ph.D

Gregor Mendel Professor of Genetics and of Medicine
617-525-4510
Elledge Lab Website
ERa-associated translocations underlie oncogene amplifications in breast cancer.
Authors: Authors: Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ.
Nature
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Ubiquitin-independent proteasomal degradation driven by C-degron pathways.
Authors: Authors: Makaros Y, Raiff A, Timms RT, Wagh AR, Gueta MI, Bekturova A, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I.
Mol Cell
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Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.
Authors: Authors: Shrock EL, Timms RT, Kula T, Mena EL, West AP, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJ.
Science
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E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Authors: Authors: Scott DC, King MT, Baek K, Gee CT, Kalathur R, Li J, Purser N, Nourse A, Chai SC, Vaithiyalingam S, Chen T, Lee RE, Elledge SJ, Kleiger G, Schulman BA.
Mol Cell
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A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
Authors: Authors: Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJ.
Mol Cell
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High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.
Authors: Authors: Bruno PM, Timms RT, Abdelfattah NS, Leng Y, Lelis FJN, Wesemann DR, Yu XG, Elledge SJ.
Nat Biotechnol
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Parasitic, bacterial, viral, immune-mediated, metabolic and nutritional factors associated with nodding syndrome.
Authors: Authors: Edridge AWD, Abd-Elfarag G, Deijs M, Broeks MH, Cristella C, Sie B, Vaz FM, Jans JJM, Calis J, Verhoef H, Demir A, Poppert S, Nickel B, van Dam A, Sebit B, Titulaer MJ, Verweij JJ, de Jong MD, van Gool T, Faragher B, Verhoeven-Duif NM, Elledge SJ, van der Hoek L, Boele van Hensbroek M.
Brain Commun
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An Editor's rave review.
Authors: Authors: Elledge SJ.
Genes Dev
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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Authors: Authors: Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I.
Cell
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Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1.
Authors: Authors: Oreskovic E, Wheeler EC, Mengwasser KE, Fujimura E, Martin TD, Tothova Z, Elledge SJ.
Proc Natl Acad Sci U S A
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