Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Systematic identification of synergistic drug pairs targeting HIV.
Authors: Authors: Tan X, Hu L, Luquette LJ, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJ.
Nat Biotechnol
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Reactivation of latent HIV-1 by inhibition of BRD4.
Authors: Authors: Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL.
Cell Rep
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Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Authors: Authors: Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ.
Mol Cell
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Recurrent hemizygous deletions in cancers may optimize proliferative potential.
Authors: Authors: Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ.
Science
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BRCA1 as tumor suppressor: lord without its RING?
Authors: Authors: Elia AE, Elledge SJ.
Breast Cancer Res
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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.
Authors: Authors: Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M.
Nat Med
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A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
Authors: Authors: Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ.
Nat Cell Biol
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A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Authors: Authors: Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF.
Science
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Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.
Authors: Authors: Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ.
Proc Natl Acad Sci U S A
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SLIC: a method for sequence- and ligation-independent cloning.
Authors: Authors: Li MZ, Elledge SJ.
Methods Mol Biol
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