Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
STOP gene Phactr4 is a tumor suppressor.
Authors: Authors: Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ.
Proc Natl Acad Sci U S A
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Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10.
Authors: Authors: Finton KA, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK.
PLoS Pathog
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Construction of a rationally designed antibody platform for sequencing-assisted selection.
Authors: Authors: Larman HB, Xu GJ, Pavlova NN, Elledge SJ.
Proc Natl Acad Sci U S A
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Systematic identification of synergistic drug pairs targeting HIV.
Authors: Authors: Tan X, Hu L, Luquette LJ, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJ.
Nat Biotechnol
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Reactivation of latent HIV-1 by inhibition of BRD4.
Authors: Authors: Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL.
Cell Rep
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Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Authors: Authors: Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ.
Mol Cell
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Recurrent hemizygous deletions in cancers may optimize proliferative potential.
Authors: Authors: Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ.
Science
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BRCA1 as tumor suppressor: lord without its RING?
Authors: Authors: Elia AE, Elledge SJ.
Breast Cancer Res
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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.
Authors: Authors: Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M.
Nat Med
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A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
Authors: Authors: Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ.
Nat Cell Biol
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