Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Global identification of modular cullin-RING ligase substrates.
Authors: Authors: Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell
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IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.
Authors: Authors: Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL.
PLoS Pathog
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Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.
Authors: Authors: Hajdu I, Ciccia A, Lewis SM, Elledge SJ.
Proc Natl Acad Sci U S A
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Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.
Authors: Authors: Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NP.
Science
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Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.
Authors: Authors: Emanuele MJ, Ciccia A, Elia AE, Elledge SJ.
Proc Natl Acad Sci U S A
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A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Authors: Authors: Cotta-Ramusino C, McDonald ER, Hurov K, Sowa ME, Harper JW, Elledge SJ.
Science
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Autoantigen discovery with a synthetic human peptidome.
Authors: Authors: Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJ.
Nat Biotechnol
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Functional identification of optimized RNAi triggers using a massively parallel sensor assay.
Authors: Authors: Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW.
Mol Cell
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Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Authors: Authors: Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF.
Cell
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The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo.
Authors: Authors: Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ.
Proc Natl Acad Sci U S A
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