Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
Authors: Authors: Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M.
PLoS Pathog
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Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.
Authors: Authors: Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ.
Mol Syst Biol
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A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.
Authors: Authors: O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW.
Mol Cell
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A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.
Authors: Authors: Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ.
Proc Natl Acad Sci U S A
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The DNA damage response: making it safe to play with knives.
Authors: Authors: Ciccia A, Elledge SJ.
Mol Cell
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A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Authors: Authors: Hurov KE, Cotta-Ramusino C, Elledge SJ.
Genes Dev
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Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
Authors: Authors: Burrows AE, Smogorzewska A, Elledge SJ.
Proc Natl Acad Sci U S A
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Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.
Authors: Authors: Fishler T, Li YY, Wang RH, Kim HS, Sengupta K, Vassilopoulos A, Lahusen T, Xu X, Lee MH, Liu Q, Elledge SJ, Ried T, Deng CX.
Oncogene
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Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
Authors: Authors: Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ.
Genes Dev
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A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Authors: Authors: Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ.
Mol Cell
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