Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
Authors: Authors: Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.
Genes Dev
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Cell biology forum: Genome-wide view of mitosis.
Authors: Authors: Swedlow JR, Cotta-Ramusino C, Elledge SJ.
Nature
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Synthetic design of strong promoters.
Authors: Authors: Schlabach MR, Hu JK, Li M, Elledge SJ.
Proc Natl Acad Sci U S A
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The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Authors: Authors: Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ.
Cell
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The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
Authors: Authors: Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC.
Science
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The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.
Authors: Authors: Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ.
Genes Dev
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A genome-wide genetic screen for host factors required for hepatitis C virus propagation.
Authors: Authors: Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ.
Proc Natl Acad Sci U S A
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Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.
Authors: Authors: Shen X, Do H, Li Y, Chung WH, Tomasz M, de Winter JP, Xia B, Elledge SJ, Wang W, Li L.
Mol Cell
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Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork.
Authors: Authors: Naylor ML, Li JM, Osborn AJ, Elledge SJ.
Proc Natl Acad Sci U S A
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Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Authors: Authors: Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW.
Cell
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