Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Authors: Authors: Hurov KE, Cotta-Ramusino C, Elledge SJ.
Genes Dev
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Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
Authors: Authors: Burrows AE, Smogorzewska A, Elledge SJ.
Proc Natl Acad Sci U S A
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Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.
Authors: Authors: Fishler T, Li YY, Wang RH, Kim HS, Sengupta K, Vassilopoulos A, Lahusen T, Xu X, Lee MH, Liu Q, Elledge SJ, Ried T, Deng CX.
Oncogene
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Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
Authors: Authors: Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ.
Genes Dev
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A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Authors: Authors: Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ.
Mol Cell
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The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
Authors: Authors: Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.
Genes Dev
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Cell biology forum: Genome-wide view of mitosis.
Authors: Authors: Swedlow JR, Cotta-Ramusino C, Elledge SJ.
Nature
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Synthetic design of strong promoters.
Authors: Authors: Schlabach MR, Hu JK, Li M, Elledge SJ.
Proc Natl Acad Sci U S A
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The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Authors: Authors: Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ.
Cell
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The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
Authors: Authors: Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC.
Science
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