Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.
Authors: Authors: Shen X, Do H, Li Y, Chung WH, Tomasz M, de Winter JP, Xia B, Elledge SJ, Wang W, Li L.
Mol Cell
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Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork.
Authors: Authors: Naylor ML, Li JM, Osborn AJ, Elledge SJ.
Proc Natl Acad Sci U S A
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Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Authors: Authors: Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW.
Cell
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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Authors: Authors: Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ.
Cell
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A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.
Authors: Authors: Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ.
Genes Dev
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NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
Authors: Authors: Wang B, Hurov K, Hofmann K, Elledge SJ.
Genes Dev
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Principles of cancer therapy: oncogene and non-oncogene addiction.
Authors: Authors: Luo J, Solimini NL, Elledge SJ.
Cell
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Design of 240,000 orthogonal 25mer DNA barcode probes.
Authors: Authors: Xu Q, Schlabach MR, Hannon GJ, Elledge SJ.
Proc Natl Acad Sci U S A
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A role for the host coatomer and KDEL receptor in early vaccinia biogenesis.
Authors: Authors: Zhang L, Lee SY, Beznoussenko GV, Peters PJ, Yang JS, Gilbert HY, Brass AL, Elledge SJ, Isaacs SN, Moss B, Mironov A, Hsu VW.
Proc Natl Acad Sci U S A
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WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Authors: Authors: Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD.
Nature
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