Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
A role for the host coatomer and KDEL receptor in early vaccinia biogenesis.
Authors: Authors: Zhang L, Lee SY, Beznoussenko GV, Peters PJ, Yang JS, Gilbert HY, Brass AL, Elledge SJ, Isaacs SN, Moss B, Mironov A, Hsu VW.
Proc Natl Acad Sci U S A
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WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Authors: Authors: Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD.
Nature
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CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Authors: Authors: Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y.
Mol Cell
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Global protein stability profiling in mammalian cells.
Authors: Authors: Yen HC, Xu Q, Chou DM, Zhao Z, Elledge SJ.
Science
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FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.
Authors: Authors: Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ.
Mol Cell
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Identification of SCF ubiquitin ligase substrates by global protein stability profiling.
Authors: Authors: Yen HC, Elledge SJ.
Science
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Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.
Authors: Authors: Li JM, Tetzlaff MT, Elledge SJ.
Cell Cycle
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FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Authors: Authors: Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M.
Nat Struct Mol Biol
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Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.
Authors: Authors: Lee YD, Wang J, Stubbe J, Elledge SJ.
Mol Cell
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RNA interference screen for human genes associated with West Nile virus infection.
Authors: Authors: Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E.
Nature
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