Stephen J. Elledge

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital

Professor of Medicine, Brigham and Women's Hospital

617-525-4510

Elledge Lab Website

Additional Websites
Publications

HHMI Investigator

Non-oncogene addiction and the stress phenotype of cancer cells.

Authors: Authors: Solimini NL, Luo J, Elledge SJ.
Cell 2007-09-21
View full abstract on Pubmed

The ubiquitin-specific protease USP28 is required for MYC stability.

Authors: Authors: Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M.
Nat Cell Biol 2007-07-01
View full abstract on Pubmed

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

Authors: Authors: Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ.
Science 2007-05-25
View full abstract on Pubmed

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Authors: Authors: Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ.
Science 2007-05-25
View full abstract on Pubmed

The tumor suppressor CYLD regulates entry into mitosis.

Authors: Authors: Stegmeier F, Sowa ME, Nalepa G, Gygi SP, Harper JW, Elledge SJ.
Proc Natl Acad Sci U S A 2007-05-22
View full abstract on Pubmed

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Authors: Authors: Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ.
Nat Cell Biol 2007-05-01
View full abstract on Pubmed

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

Authors: Authors: Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ.
Cell 2007-04-20
View full abstract on Pubmed

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

Authors: Authors: Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.
Nature 2007-04-19
View full abstract on Pubmed

Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.

Authors: Authors: Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TW.
Proc Natl Acad Sci U S A 2007-03-06
View full abstract on Pubmed

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.

Authors: Authors: Li MZ, Elledge SJ.
Nat Methods 2007-03-01
View full abstract on Pubmed