Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Authors: Authors: Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ.
Nat Cell Biol
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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Authors: Authors: Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ.
Cell
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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
Authors: Authors: Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.
Nature
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Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.
Authors: Authors: Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TW.
Proc Natl Acad Sci U S A
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Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.
Authors: Authors: Li MZ, Elledge SJ.
Nat Methods
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Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.
Authors: Authors: Chou DM, Elledge SJ.
Proc Natl Acad Sci U S A
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Lessons from Nature: microRNA-based shRNA libraries.
Authors: Authors: Chang K, Elledge SJ, Hannon GJ.
Nat Methods
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A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.
Authors: Authors: Zhang D, Zaugg K, Mak TW, Elledge SJ.
Cell
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Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.
Authors: Authors: Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L.
Mol Cell
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ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.
Authors: Authors: Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX.
EMBO J
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